Clinical and immunological response to sublingual allergen-specific immunotherapy: cumulative dose-response relationship | ||
| Egyptian Journal of Medical Microbiology | ||
| Volume 33, Issue 3, July 2024, Pages 25-31 PDF (318.45 K) | ||
| Document Type: New and original researches in the field of Microbiology. | ||
| DOI: 10.21608/ejmm.2024.290825.1250 | ||
| Authors | ||
| Heba W. Abdelwahab1; Amina Abd El-Maksoud1; Mohamed A. Elmoneim1; Mona Shaaban2; Mohammed A. Abu El-Enin3; Fathalla Belal4; Abeer Mohamed Abd El-Aziz* 2 | ||
| 1Chest Medicine Department, Mansoura University, Egypt | ||
| 2Microbiology & Immunology Department, Faculty of Pharmacy, Mansoura University, Egypt | ||
| 3Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Egypt; Department of Pharmacy, Basrah University, College of Science and Technology, Basra 61004, Iraq | ||
| 4Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Mansoura University, Egypt | ||
| Abstract | ||
| Background: Initial studies on sublingual allergen-specific immunotherapy (SLIT) used low doses, but it soon became clear that cumulative dosages higher than the doses used in subcutaneous immunotherapy (SCIT) were required to guarantee clinical efficacy. Objective: This study aimed to evaluate the cumulative dose-dependent clinical and immunological responses to SLIT. Methodology: Patients with allergic airway diseases were included in the study. Patients underwent a skin prick test (SPT) and then received sublingual allergen-specific immunotherapy. Clinical and immunological response variables were recorded at 0, 3, and 6 months intervals of the SLIT schedule (with progressively increasing doses). Results: The study included 74 patients with allergic airway diseases. Symptom and medication scores significantly decreased from baseline (P <0.0001). Hay-specific IgE levels did not decrease significantly, but mite-specific IgE levels decreased by 146%. Hay-specific IgG4 levels increased by 44. 44% after six months of immunotherapy (P<0.01). Eosinophil cationic protein (ECP) levels decreased significantly in patients who underwent six months of sublingual-swallow immunotherapy. Conclusion: There is a clinical cumulative dose-response relationship after SLIT. However, apart from ECP, the immunological cumulative dose-response relationship varies between the allergens. | ||
| Keywords | ||
| Sublingual-swallow immunotherapy (SLIT); immunological response; clinical response; dose-response relationship; specific IgG4 | ||
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