Eosinophilic Esophagitis among Patients with Refractory Gastroesophageal Reflux Disease

Rizk, Mahmoud; Mohamed, Ahmed Refaat; K. ElAlfy, Amira; A. ElAssal, Mohamed; Gergis, Mina Nasrallah; Abd Ellatif Afifi, Mohamed

doi:10.21608/bmfj.2024.283674.2061

	Eosinophilic Esophagitis among Patients with Refractory Gastroesophageal Reflux Disease
Benha Medical Journal
Article 15, Volume 41, Issue 8, December 2024, Page 550-560 PDF (632.99 K)
Document Type: Original Article
DOI: 10.21608/bmfj.2024.283674.2061
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Authors
Mahmoud Rizk¹; Ahmed Refaat Mohamed²; Amira K. ElAlfy²; Mohamed A. ElAssal³; Mina Nasrallah Gergis ⁴; Mohamed Abd Ellatif Afifi⁵
¹Department of Internal Medicine, Faculty of Medicine, Benha University, Egypt
²Lecturer of Internal Medicine Faculty of medicine - Benha University
³Professor of Internal Medicine Head of internal medicine department Faculty of medicine - Benha University
⁴Internal Medicine Department, Faculty of Medicine, Benha University, Egypt
⁵Assistant Professor of Internal Medicine Faculty of medicine - Benha University
Abstract
Background: Eosinophilic esophagitis (EoE) may be linked to gastroesophageal reflux disease (GERD) in as many as 30% of patients of EoE. We aimed to study the prevalence and clinical presentation of Eosinophilic esophagitis among patients with refractory GERD. Methods: This cross-sectional study was conducted on 181 patients presented with persistent GERD symptoms despite double dose PPI therapy for at least 8 weeks without interruption, who were referred to gastroenterology unit of Internal Medicine Department at Benha University Hospitals. All patients were subjected to proper and detailed history taking and thorough clinical examination, laboratory investigations including complete blood count with differential leucocytic count and upper gastrointestinal endoscopy and biopsy for histopathological examination. Results: The mean age of these patients was 36.7±11.46. 103 (56.9%) patients were males and 78 (43.1%) were females. Among the studied cases, 9 (5.0%) cases had EoE and 2 (1.1%) cases had eosinophilic gastroenteritis. Peripheral eosinophilia was found in 6 (66.7%) of EoE cases. EoE cases had statistically significant higher incidence of atopy, dysphagia, food impaction, furrows, white plaques, concentric rings and strictures compared to refractory GERD patients without EoE (P
Keywords
Eosinophilic Esophagitis; Refractory GERD; Dysphagia; Food Impaction; Peripheral Eosinophilia


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