Serum Creatinine/Cystatin C Ratio in Chronic Obstructive Pulmonary Disease Patients and its Corelation to Disease Severity | ||||
| Benha Medical Journal | ||||
| Article 599, Volume 41, Issue 2, May and June 2024, Page 205-219 PDF (739.91 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bmfj.2024.284759.2065 | ||||
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| Authors | ||||
Marwa Elsayed Elnaggar1; Ahmed Abdelsadek Mohamed2; Maha Mamdouh Osman 3; enas mohammed sweed 4; Hagar Ismael Elshahat  5; Etemad Abdelsalam Mohammed6
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| 1Assistant professor of Chest Diseases, Faculty of Medicine, Benha University | ||||
| 2Professor of Chest Diseases, Faculty of Medicine, Benha University | ||||
| 3Lecturer of clinical and chemical pathology department, Faculty of medicine, Helwan University | ||||
| 4Assistant professor of radiology Department , Faculty of medicine– Banha University | ||||
| 5master degree in chest diseases and tuberculosis | ||||
| 6Lecturer of Chest Diseases, Faculty of Medicine, Benha University | ||||
| Abstract | ||||
| Background: Muscle atrophy is a major clinical feature of chronic obstructive pulmonary disease (COPD), and it is considered a strong predictor of mortality in COPD patients. This study aimed to assess the use of serum creatinine/serum Cystatin C ratio in the assessment of muscle wasting and disease severity in stable COPD patients. Methods: This case-control study included 70 COPD patients and 20 age and gender-matched healthy controls. Pulmonary function tests, measurement of the serum creatinine (Cr) and cystatin C (Cys-C) levels, chest high-resolution CT images (HRCT) for the assessment of low attenuation area percentage (LAA%) and Erector Spinae muscle (ESM) thickness, routine laboratory investigations and arterial blood gases (ABG). Results: There was a significant positive correlation between serum cystatin c and severity of COPD and LAA% but there was a significant negative correlation between serum cystatin c and Erector Spinae muscle cross-sectional area (ESMCSA), forced vital capacity %predicted (FVC% predicted), forced expiratory volume in 1 second (FEV1%predicted) FEV1/FVC%, and body mass index (BMI). Moreover, there was a significant positive correlation between creatinine/ cysC ratio and BMI, ESMCSA, FVC% predicted, FEV1/ FVC % and FEV1% predicted. The cut-off points of ESMCSA and Cr/Cys C for severe COPD were 23.4 cm2 and 0.87 respectively. Conclusion: The present study indicated that the Cr/Cys C ratio is an easy, inexpensive, repeatable, and promising tool that allows us to evaluate muscle wasting in COPD patients using serum markers as there is a positive correlation between the degree of muscle wasting and the severity of COPD. | ||||
| Keywords | ||||
| COPD; Creatinine/Cystatin C Ratio; ESMCSA; Disease Severity | ||||
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