Efficiency of Platelet-Rich Plasma in Repairing Tympanic Membrane Perforation
Abdelazez farag, A., Eskander, N., Madian, Y., Ashry, Y. (2023). Efficiency of Platelet-Rich Plasma in Repairing Tympanic Membrane Perforation. EKB Journal Management System, 26(10), 35-44. doi: 10.21608/scumj.2023.357513
Ahmed M. Abdelazez farag; Nagy M. Eskander; Yasser T. Madian; Yehia M. Ashry. "Efficiency of Platelet-Rich Plasma in Repairing Tympanic Membrane Perforation". EKB Journal Management System, 26, 10, 2023, 35-44. doi: 10.21608/scumj.2023.357513
Abdelazez farag, A., Eskander, N., Madian, Y., Ashry, Y. (2023). 'Efficiency of Platelet-Rich Plasma in Repairing Tympanic Membrane Perforation', EKB Journal Management System, 26(10), pp. 35-44. doi: 10.21608/scumj.2023.357513
Abdelazez farag, A., Eskander, N., Madian, Y., Ashry, Y. Efficiency of Platelet-Rich Plasma in Repairing Tympanic Membrane Perforation. EKB Journal Management System, 2023; 26(10): 35-44. doi: 10.21608/scumj.2023.357513

Efficiency of Platelet-Rich Plasma in Repairing Tympanic Membrane Perforation

Suez Canal University Medical Journal
Article 5, Volume 26, Issue 10, October 2023, Page 35-44  XML PDF (433.41 K)
Document Type: Original Article
DOI: 10.21608/scumj.2023.357513
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Authors
Ahmed M. Abdelazez farag email 1; Nagy M. Eskander2; Yasser T. Madian2; Yehia M. Ashry2
1Department of Otorhinolaryngology, Military Production Hospital.
2Department of Otorhinolaryngology, Faculty of Medicine-Suez Canal University
Abstract
Background: Myringoplasty is the definite treatment of tympanic membrane perforation. Aim: This study aimed to assess the success rate in repairing tympanic membrane perforation of Platelet platelet-rich plasma myringoplasty method. Patients and Methods: In our study, we have 27 TM perforations in 24 patients (where 3 patients had bilateral perforation) with small and medium-sized tympanic membrane perforations. We excluded subtotal or marginal perforation. In our study, Myringoplasty involves the repair of tympanic membrane perforation with a Platelet-rich plasma graft. Platelet-rich plasma graft was used as an overlay graft through the EAC under local anesthesia to act as a support for the Tympanic membrane to grow on both sides of the Platelet-rich plasma graft and enhance the success rate through its growth factors. Results: Graft uptake and complete closure of tympanic membrane were observed in 87.5% of cases (85.2% in relation to a number of perforations), Small-sized TM perforation documented 93.3% success rate (14 perforations of 15), while medium-sized TM perforation documented 75% success rate (9 perforations of 12). Platelet-rich plasma graft provides a better audiological result, hearing gain by >10 dB was achieved in 87.5% of patients. Conclusion: Platelet-rich plasma is a highly successful auto graft for closure of small tympanic perforations, fairly successful in medium-sized perforation, and provides unlimited graft material for residual perforations after failure fascia graft.
 
Keywords
PRP; Myringoplasty; Tympanic membrane perforation
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