Gene Expression of Oxidative/Antioxidative Markers, VDR, CAMK4 and Ceruloplasmin in Baladi Sheep with Minerals Deficiency
Emam, R., Ghanem, P., Abdel-Raof, Y., EL-khaiat, H., Elsayed, A., Helal, M. (2025). Gene Expression of Oxidative/Antioxidative Markers, VDR, CAMK4 and Ceruloplasmin in Baladi Sheep with Minerals Deficiency. EKB Journal Management System, 56(5), 1121-1133. doi: 10.21608/ejvs.2024.280240.1971
Rania Emam; Prof Mohamed M Ghanem; Yassine Abdel-Raof; Heba M. EL-khaiat; Ahmed Adel Elsayed; Mahmoud Atef Helal. "Gene Expression of Oxidative/Antioxidative Markers, VDR, CAMK4 and Ceruloplasmin in Baladi Sheep with Minerals Deficiency". EKB Journal Management System, 56, 5, 2025, 1121-1133. doi: 10.21608/ejvs.2024.280240.1971
Emam, R., Ghanem, P., Abdel-Raof, Y., EL-khaiat, H., Elsayed, A., Helal, M. (2025). 'Gene Expression of Oxidative/Antioxidative Markers, VDR, CAMK4 and Ceruloplasmin in Baladi Sheep with Minerals Deficiency', EKB Journal Management System, 56(5), pp. 1121-1133. doi: 10.21608/ejvs.2024.280240.1971
Emam, R., Ghanem, P., Abdel-Raof, Y., EL-khaiat, H., Elsayed, A., Helal, M. Gene Expression of Oxidative/Antioxidative Markers, VDR, CAMK4 and Ceruloplasmin in Baladi Sheep with Minerals Deficiency. EKB Journal Management System, 2025; 56(5): 1121-1133. doi: 10.21608/ejvs.2024.280240.1971

Gene Expression of Oxidative/Antioxidative Markers, VDR, CAMK4 and Ceruloplasmin in Baladi Sheep with Minerals Deficiency

Egyptian Journal of Veterinary Sciences
Volume 56, Issue 5, May 2025, Page 1121-1133  XML PDF (1.21 MB)
Document Type: Original Article
DOI: 10.21608/ejvs.2024.280240.1971
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Authors
Rania Emam email 1; Prof Mohamed M Ghanem2; Yassine Abdel-Raof3; Heba M. EL-khaiat4; Ahmed Adel Elsayed5; Mahmoud Atef Helal6
1Animal Medicine Department, Faculty of Veterinary Medicine, Benha University, Moshtohor, Toukh, Egypt.
2Animal Medicine Department, Faculty of Veterinary Medicine, Benha University, Moshtohor, Toukh, Egypt
3Animal Medicine Department, Faculty of Veterinary Medicine, Benha University, Moshtohor, Toukh, Egypt
4Animal Medicine Department, Faculty of Veterinary Medicine, Benha University, Moshtohor, Toukh, Egypt,
5Department of Animal Health and Poultry, Animal and Poultry Production Division, Desert Research Center (DRC), Mataryia, Cairo, Egypt.
6Animal medicine department faculty of veterinary medicine benha university
Abstract
The objective of this work was to elaborate gene expression and serum profile of oxidative/antioxidant and bone markers associated with minerals deficiency and their correlation with mineral deficiency in sheep. The study was carried out on 26 selected diseases cases out of survey on 250 sheep suffered from mineral deficiency compared to 10 apparent healthy control sheep based on clinical examination. Biochemically, there was a significant (P<0.05) decline in Ca, P, Mg, Cu, Zn, Se, Fe, TAC, GPx, SOD, CAT, OC and CP, whereas MDA level was significantly increased (P<0.05). Gene expression of SOD, CAT, GPX1, VDR, CAMK4 and ceruloplasmin genes were significantly down-regulated (P<0.05) in diseased sheep. A contrary tendency was evoked by the gene OXSR1.The variability in studied genes alongside alterations in the serum profile of investigated markers could be a reference guide for limiting the mineral deficiency in sheep through prescribing an efficient nutritional management strategy for sheep flocks that includes the essential macro- and micro aspects, and not depend just on grazing as a primary source of feed to sustain sheep health and output.
Keywords
Gene expression; micro-macro element; oxidative/antioxidant markers; bone marker; sheep
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