Transthyretin Amyloidosis (ATTR-CM) | ||||
| Cardiovascular Research Prove Journal | ||||
| Articles in Press, Accepted Manuscript, Available Online from 03 June 2024 | ||||
| Document Type: Abstracts | ||||
| DOI: 10.21608/cvrepj.2024.288456.1004 | ||||
 View on SCiNiTO | ||||
| Author | ||||
ELINA HAMED ELNTEIK 
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| HEALTH CENTER OF GLIFADA | ||||
| Abstract | ||||
| Transthyretin cardiac amyloidosis (ATTR-CM) is an underdiagnosed, life-threatening disease linked to heart failure. TRANSTYRETIN (TTR), is a natural transport protein that becomes unstable. First of aThat unstable TTR protein folds abnormally and forms aggregations of amyloid fibrous, which can deposit in the heart and other areas of the body. The Accumulation of that protein causes the progressive stiffness of the myocardium which leads to Heart Failure. The two types of transthyretin amyloidosis (ATTR-CM) include: • Familial (Hereditary) ATTR-CM • Wild-type ATTR-CM The first step in suspecting ATTR-CM is to watch for the following signs and symptoms. Because of the way it affects the heart, ATTR-CM often presents with symptoms of heart failure. We may order the tests to evaluate your heart's function and check for any signs of ATTR-CM such as Echocardiogram,Cardiac MRI ,Scintigraphy (SPECT test),Myocardial biopsy,Genetic testing,etc. EARLY DIAGNOSIS IS IMPORTANT FOR PROPER TREATMENT OF ATTR-CM. Once ATTR-CM is diagnosed, genetic testing and counseling are recommended. Genetic testing can confirm or rule out the inherited form of ATTR-CM (HATTR).There’s a 50% chance of passing it to each of your children.Treatment of ATTR Amyloidosis includes stabilizers of the Transthyretin tetramer and drugs that stop the production of Transthyretin by destroying its mRNA before it makes it to the ribosomes. For Transthyretin Amyloidosis, until today, a stabilizer of the Transthyretin tetramer,Tafamidis, is used. AG10 or Acoramidis under investigation,CONCLUSIONS It is important to get an accurate diagnosis as soon as possible, because treatments may be more successful if started early. | ||||
| Keywords | ||||
| Transthyretin amyloidosis; Symptoms; heart failure | ||||
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