EFFECT OF ASPARTAME ON ALBINO RATS’ PAROTID SALIVARY GLANDS (LIGHT MICROSCOPIC STUDY)
Elfarnwany, H., Younis, S., El-darier, S., Eissa, A. (2025). EFFECT OF ASPARTAME ON ALBINO RATS’ PAROTID SALIVARY GLANDS (LIGHT MICROSCOPIC STUDY). EKB Journal Management System, 50(2), 31-37. doi: 10.21608/adjalexu.2024.246695.1437
Hagar Elsayed Elfarnwany; Salwa Abdelsamad Younis; Salama M. El-darier; Amira Salama Eissa. "EFFECT OF ASPARTAME ON ALBINO RATS’ PAROTID SALIVARY GLANDS (LIGHT MICROSCOPIC STUDY)". EKB Journal Management System, 50, 2, 2025, 31-37. doi: 10.21608/adjalexu.2024.246695.1437
Elfarnwany, H., Younis, S., El-darier, S., Eissa, A. (2025). 'EFFECT OF ASPARTAME ON ALBINO RATS’ PAROTID SALIVARY GLANDS (LIGHT MICROSCOPIC STUDY)', EKB Journal Management System, 50(2), pp. 31-37. doi: 10.21608/adjalexu.2024.246695.1437
Elfarnwany, H., Younis, S., El-darier, S., Eissa, A. EFFECT OF ASPARTAME ON ALBINO RATS’ PAROTID SALIVARY GLANDS (LIGHT MICROSCOPIC STUDY). EKB Journal Management System, 2025; 50(2): 31-37. doi: 10.21608/adjalexu.2024.246695.1437

EFFECT OF ASPARTAME ON ALBINO RATS’ PAROTID SALIVARY GLANDS (LIGHT MICROSCOPIC STUDY)

Alexandria Dental Journal
Article 5, Volume 50, Issue 2, August 2025, Page 31-37  XML PDF (672.21 K)
Document Type: Original Article
DOI: 10.21608/adjalexu.2024.246695.1437
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Authors
Hagar Elsayed Elfarnwany email orcid 1; Salwa Abdelsamad Younis2; Salama M. El-darier3; Amira Salama Eissaorcid 4
1Oral biology department, faculty of dentistry, Alexandria university
2Department of Oral Biology, Faculty of Dentistry, Alexandria University, Alexandria, Egypt
3Professor of Botany, Botany and Microbiology Department, Faculty of Science, Alexandria University.
4Oral biology department, Faculty of Dentistry, Alexandria University, Alexandria, Egypt
Abstract
ABSTRACT
Introduction: Aspartame (ASP) is a widely used synthetic sweetener around the world. Its sweetness power is nearly 200 times that of sucrose. It is added to many products, such as diet soda and yogurt. Upon long term uptake of ASP, the balance between oxidants and antioxidants is disturbed leading to oxidative stress and peroxidation of lipid. Additionally, it causes degenerative changes regarding different body organs.
Objectives to evaluate the effect of aspartame on the rats’ parotid salivary glands.
Methodology: Sixteen male albino rats (170-210 g in weight) were randomly split into: Group I (control group), Group II (ASP group). Using oral gavage, group I rats were given 1 ml distilled water once a day while group II rats were given 250 mg/kg body weight of ASP dissolved in distilled water once a day for 8 weeks. After 8 weeks, the animals were euthanized, the parotid glands were surgically removes and the effect of ASP was evaluated using a light microscope.
Results: Normal histological features of parotid gland were demonstrated in the control group. Regarding the ASP group, structural disorganization as well as extensive vacuolation were seen in the serous acini. According to body weight changes, there was an increase in body weight within the group receiving ASP.
Conclusion: Oral administration of ASP for 8 weeks in male rats led to significant histological alterations in the parotid salivary glands and thus oral homeostasis disruption.
Keywords
Aspartame; ASP; Parotid salivary glands; Albino rats
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