EVALUATION OF MAST CELLS EXPRESSION IN THE SKIN OF PEMPHIGUS VULGARIS AND BULLOUS PEMPHIGOID PATIENTS

Mohamed, Nagat Sobhy; Hassan, Eman Mohamad; Allam, Maram Mohammed Naguib; Ibrahim Abd Ellatif, Asmaa Hamada

doi:10.21608/alexpo.2024.294365.1851

	EVALUATION OF MAST CELLS EXPRESSION IN THE SKIN OF PEMPHIGUS VULGARIS AND BULLOUS PEMPHIGOID PATIENTS
ALEXMED ePosters
Article 1, Volume 6, Issue 2, April 2024, Page 29-30
Document Type: Preliminary preprint short reports of original research
DOI: 10.21608/alexpo.2024.294365.1851
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Authors
Nagat Sobhy Mohamed¹; Eman Mohamad Hassan¹; Maram Mohammed Naguib Allam²; Asmaa Hamada Ibrahim Abd Ellatif ¹
¹Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Alexandria University
²Department of pathology, Faculty of Medicine,University of Alexandria.
Abstract
INTRODUCTION Pemphigus vulgaris (PV) and Bullous pemphigoid (BP) are well-known chronic autoimmune bullous dermatoses in which antibodies are directed against basement membrane zone. Mast cells contribution in inflammatory and autoimmune diseases is recently suggested. AIM OF THE WORK The aim of this study was to detect mast cells expression in pemphigus vulgaris and Bullous pemphigoid skin lesions. PATIENTS The work protocol were as follow: • Patients were recruited from the Dermatology Outpatient Clinic of the Alexandria Main University Hospital. This study were conducted on: • 20 pemphigus vulgaris patients (Group I). • 20 Bullous pemphigoid patients (Group II). • 10 healthy persons as control (safety margin of basel cell carcinoma and squamous cell carcinoma patients. METHODS Mast cells detection in skin biopsies were done by using immunohistochemical staining for CD117. Results mast cells showed significant higher presentation of (25-50% involvement) in group I than in group II (60% VS 15% of patients respectively).
Keywords
PEMPHIGUS VULGARIS; MAST CELLS; SKIN
Supplementary Files 1851 Asmaa Hamada Ibrahim Abd Ellatif.pdf

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