Added value of PET/CT in Staging and Follow up of Bronchogenic Carcinoma | ||||
| Zagazig University Medical Journal | ||||
| Volume 30, Issue 6, September 2024, Page 2509-2521 PDF (1.05 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zumj.2024.288447.3390 | ||||
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| Authors | ||||
ahmed fekry salem   1; Mohamed Abdel razigh Mohamed Bouzied2; Ayman fathy Amer3; Ghada Adel AbdelHamid4; Asmaa Abdallah Alshamy5
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| 1Department of Radiodiagnosis, Zagazig University, Zagazig, Egypt | ||||
| 2Faculty of Medicine – Benghazi University - Libya | ||||
| 3radiodiagnosis department, faculty of medicine, zagazig, egypt. | ||||
| 4Radio diagnosis faculty of medicine and Zagazig university hospitals | ||||
| 5radiodiagnosis department, faculty of medicine, zagazig university | ||||
| Abstract | ||||
| Background: Among the most frequent causes of cancer-related mortality is bronchogenic carcinoma. Radiological imaging is essential for prognosis prediction and therapy planning. PET/CT greatly improves management approach and offer more accurate staging and follow up. The study's objective is to assess PET/CT impact on lung cancer restaging and follow up. Methods: This prospective cross-sectional study included 48 cases of pathologically confirmed bronchogenic carcinoma incorporated for staging and follow-up after therapy. Every patient had PET/CT, and the data was analyzed using TNM staging also RECIST and PERCIST criteria used for treatment response assessment. Results: PET/CT resulted in modification in TNM staging for 16 patients and 12 patients showed various surgical staging. In follow up group, ten cases had differences between RECIST and PERCIST results with the majority of them (6 cases) displayed alteration from partial response to stable response. When pre- and post-treatment SUVs in responder and non-responder groups were compared, it was found that responder group's post-treatment SUV was significantly lower than baseline SUV (P<0.001). With an AUC of 0.948, P value <0.001, and at a cutoff value of ≤9, we discovered that post-treatment SUV can successfully distinguish responders from non-responders with 100% sensitivity, 63.64% specificity, 76.55% PPV, and 100% NPV and ∆ SUV can distinguish with 100% sensitivity and 54.55% specificity. Conclusion: PET/CT was found to be reliable and efficient in assessment of tumor, nodal and metastatic staging leading to significant impact on TNM staging of bronchogenic carcinoma and provide a more comprehensive and functional therapy assessment. | ||||
| Keywords | ||||
| Bronchogenic carcinoma; PET/CT; SUV; RECIST; PERCIST | ||||
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