The Ameliorative Effect of Lycopene Against Sodium Fluoride Induced Renal Injury in Male Albino Rats (Wistar albino)
ELkady, L., El rayes, S., Soliman, A., Shanab, O., Khalil, W., Aboulelthana, W., badr, K. (2024). The Ameliorative Effect of Lycopene Against Sodium Fluoride Induced Renal Injury in Male Albino Rats (Wistar albino). EKB Journal Management System, 6(1), 48-53. doi: 10.21608/aels.2024.293052.1058
Lamees Ahmed ELkady; Samir Mohamed El rayes; Aida Hamed Soliman; Obied Shanab; Waleed F. Khalil; Wael Mahmoud Aboulelthana; kholoud badr. "The Ameliorative Effect of Lycopene Against Sodium Fluoride Induced Renal Injury in Male Albino Rats (Wistar albino)". EKB Journal Management System, 6, 1, 2024, 48-53. doi: 10.21608/aels.2024.293052.1058
ELkady, L., El rayes, S., Soliman, A., Shanab, O., Khalil, W., Aboulelthana, W., badr, K. (2024). 'The Ameliorative Effect of Lycopene Against Sodium Fluoride Induced Renal Injury in Male Albino Rats (Wistar albino)', EKB Journal Management System, 6(1), pp. 48-53. doi: 10.21608/aels.2024.293052.1058
ELkady, L., El rayes, S., Soliman, A., Shanab, O., Khalil, W., Aboulelthana, W., badr, K. The Ameliorative Effect of Lycopene Against Sodium Fluoride Induced Renal Injury in Male Albino Rats (Wistar albino). EKB Journal Management System, 2024; 6(1): 48-53. doi: 10.21608/aels.2024.293052.1058

The Ameliorative Effect of Lycopene Against Sodium Fluoride Induced Renal Injury in Male Albino Rats (Wistar albino)

Advances in Environmental and Life Sciences
Volume 6, Issue 1, July 2024, Page 48-53  XML PDF (434.81 K)
Document Type: Original research articles
DOI: 10.21608/aels.2024.293052.1058
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Authors
Lamees Ahmed ELkady1; Samir Mohamed El rayes email orcid 1; Aida Hamed Soliman1; Obied Shanab2; Waleed F. Khalil3; Wael Mahmoud Aboulelthanaorcid 4; kholoud badr email 1
1Department of Chemistry, Faculty of Sciences, Suez Canal University, Ismailia, 41522, Egypt
2Department of Biochemistry, Faculty of Veterinary Medicine, South Valley University, Qena 83523, Egypt
3Department of Veterinary Pharmacology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, 41522, Egypt
4Department of Biochemistry, Biotechnology Research Institute, National Research Centre, 33 El Bohouth St. (Former El Tahrir St.), P.O. 12622, Dokki, Giza, Egypt
Abstract
The current study aims to investigate the preventive efficacy of lycopene (LP) against sodium fluoride (NaF)-induced renal damage in rats. Four equal groups (6 rats/group) of albino rats with initial average weight 120 ± 10g were assigned as follows: G1 rats served as controls, whereas G2 rats received LP orally (10 mg/kg B.W per day); G3 rats were administered NaF (100 mg/L) in drinking water, and G4 rats were given NaF along with LP. After four weeks of the experimental period, blood samples were collected to estimate urea and creatinine levels in sera. Kidney tissues were also collected to investigate the following parameters: superoxide dismutase (SOD), glutathione reduced content (GSH), malondialdehyde (MDA) and tumor necrosis factor-α (TNF-α) in tissue homogenate. The present data declared that NaF reduced renal antioxidants SOD and GSH while elevating the levels of urea and creatinine, MDA, as well as TNF-α. Administration of LP to NaF-treated rats restored the levels of renal antioxidants and ameliorated the elevated levels of renal biomarkers, MDA, and TNF-α. The study demonstrated that LP supplementation provided strong antioxidant and anti-inflammatory protection against nephrotoxicity caused by NaF.
Keywords
Fluorosis (NaF); Oxidative stress; Lycopene; antioxidants; Tumor necrosis factor-α
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