Role of Hypovitaminosis D in Diabetes-Related Anemia of Chronic Disease and Value of Its Replacement in Response to Therapy: A Randomized Control Trial | ||
| Benha Medical Journal | ||
| Article 8, Volume 41, Issue 8, December 2024, Pages 470-480 PDF (680.45 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bmfj.2024.274818.2035 | ||
| Authors | ||
| Amr M. El Hammady1; Medhat A.Khalil2; Yomna Mohamed Marei3; Mahasen Hamdy Mohammed Ahmed* 4; Mysara Mohamed Mogahed1 | ||
| 1Assistant Professor of Internal Medicine, Faculty of Medicine, Benha University | ||
| 2Assistant Professor of Internal Medicine, Faculty of Medicine, Benha University | ||
| 3Lecture of Internal Medicine, Faculty of Medicine, Benha University | ||
| 4Departmet of Internal Medicine Faculty of Medicine- Benha University | ||
| Abstract | ||
| Background: Deficiency of vitamin D has become a global public health problem, with nearly 1 billion people worldwide being in a state of vitamin D insufficiency or deficiency. The aim of this work was to evaluate the role of hypovitaminosis D in diabetes- related anemia of chronic disease and value of its replacement in response to therapy. Methods: This randomized control trial included patients with diabetes- related anemia of chronic disease), the least Number is 318 patients. The three groups were randomized equally; group 1 was with diabetes- related anemia of chronic disease) with normal 25 hydroxy vitamin D and received treatment for anemia, group 2 was with diabetes- related anemia of chronic disease with low level of 25 hydroxy vitamin D, and group 3 was with diabetes but no anemia then follows up for hemoglobin concentration. Those Patients were informed about using vitamin D in treatment (benefits and side effects) in addition to treatment of specific anemia, then we assessed anemia after three months . Results: The study found no significant difference in age, sex, or type of diabetes mellitus (DM) between groups. However, individuals with anaemia, particularly those with low vitamin D levels, had lower serum iron and TIBC levels and higher ferritin levels. Vitamin D levels were negatively correlated with ferritin and positively correlated with iron and TIBC. HbA1C levels had negative correlations with iron, TIBC, and WBCs.Conclusions: The current study suggested that there was close relationship between vitamin D deficiency and anemia in diabetic patients. | ||
| Keywords | ||
| Hypovitaminosis D; Diabetes-Related Anemia; Chronic Disease; Replacement; Therapy | ||
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