Plasma level of MiR- 200b in type 2 diabetic retinopathy in Egyptian patients
Rageh, I., Ahmad, E., El-Mohamady, M., Mashhour, M., Zeiada, R., Abdelmotaleb, D. (2024). Plasma level of MiR- 200b in type 2 diabetic retinopathy in Egyptian patients. EKB Journal Management System, 41(8), 585-595. doi: 10.21608/bmfj.2024.289866.2081
Ibrahim Mohamed Rageh; Enas Sebaey Ahmad; Mohamed Nagy El-Mohamady; Mirna Mashhour; Rehab Adel Zeiada; Dina Saad Abdelmotaleb. "Plasma level of MiR- 200b in type 2 diabetic retinopathy in Egyptian patients". EKB Journal Management System, 41, 8, 2024, 585-595. doi: 10.21608/bmfj.2024.289866.2081
Rageh, I., Ahmad, E., El-Mohamady, M., Mashhour, M., Zeiada, R., Abdelmotaleb, D. (2024). 'Plasma level of MiR- 200b in type 2 diabetic retinopathy in Egyptian patients', EKB Journal Management System, 41(8), pp. 585-595. doi: 10.21608/bmfj.2024.289866.2081
Rageh, I., Ahmad, E., El-Mohamady, M., Mashhour, M., Zeiada, R., Abdelmotaleb, D. Plasma level of MiR- 200b in type 2 diabetic retinopathy in Egyptian patients. EKB Journal Management System, 2024; 41(8): 585-595. doi: 10.21608/bmfj.2024.289866.2081

Plasma level of MiR- 200b in type 2 diabetic retinopathy in Egyptian patients

Benha Medical Journal
Article 18, Volume 41, Issue 8, December 2024, Page 585-595  XML PDF (886.73 K)
Document Type: Original Article
DOI: 10.21608/bmfj.2024.289866.2081
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Authors
Ibrahim Mohamed Rageh1; Enas Sebaey Ahmad2; Mohamed Nagy El-Mohamady3; Mirna Mashhour4; Rehab Adel Zeiada email 5; Dina Saad Abdelmotaleborcid 6
1Professor of Clinical and Chemical Pathology - Immunology Faculty of Medicine - Benha University
2Assistant professor of Clinical and Chemical pathology Faculty of Medicine - Benha University
3Assistant professor of Ophthalmology Faculty of Medicine - Benha University
4Internal Medicine Fellowship Trainee Benha Health Insurance Hospital
5department of of Clinical and Chemical pathology Faculty of Medicine - Benha University
6Lecturer of Clinical and Chemical Pathology, Faculty of Medicine, Benha University
Abstract
Background: The incidence of diabetes mellitus is rapidly increasing, and it frequently causes considerable metabolic disorders and serious consequences. MicroRNA-200b (miR-200b) is a regulator of angiogenesis that has emerged as a diagnostic and predictive tool for certain disorders. Aim: to investigate the association of miR-200b with diabetic retinopathy (DR). Methods: The study included 100 subjects from Benha University Hospital: 40 patients with type 2 diabetes (T2D) without DR, 40 with T2D and DR, and 20 healthy controls. MicroRNA-200b was assessed for all subjects using real time PCR with SYBR Green. Results: Diabetics had lower levels of miR-200b than healthy controls. While, those without DR had even lower miR-200b levels compared to those who did have DR. Additionally, lower miR-200b levels were associated with neuropathy but not with nephropathy. Conclusion: MiR-200b showed promise as a biomarker for both T2D and DR. It perfectly differentiated diabetic patients with and without retinopathy, while offering moderate accuracy for diagnosing diabetes in general. These findings suggest miR-200b may play a risky role in DR among diabetics, and further research is warranted to confirm these results.
Keywords
T2D; diabetic retinopathy; miR-200b; micro-RNA
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