Impact of carotenoids on ulcerative colitis induced colorectal cancer - A review

AL-Noshokaty, Tohada M.; Abdelmaksoud, Nourhan M.; Abulsoud, Ahmed I.; Ahmed, Ahmed A.; Elsawy, Alaa A.; Elsayed, Amira G.; Shihata, Antonios T.; Bakhom, Anton V.; Hassan, Ashraqat M.; Badawy, Aya G.; Elsayed, Aya M.; Louis, Basanty M.; Kamel, Eman M.; Gaber, Kholoud S.; Gouda, Malak A.; Abdelwahab, Manar E.; Kamel, Marina A.; Nasry, Mina G.; Ayad, Mera N.; Talkan, Mohamed A.; Abulhamd, Omnia S.; Abdelsalam, Samaa H.; Bedeer, Seham M.; Yaseen, Tasneem G.; Abdelaziz, Yara I; Yousef, Youstena A.; Elshaer, Shereen S

doi:10.21608/ijhr.2024.274027.1001

AL-Noshokaty, T., Abdelmaksoud, N., Abulsoud, A., Ahmed, A., Elsawy, A., Elsayed, A., Shihata, A., Bakhom, A., Hassan, A., Badawy, A., Elsayed, A., Louis, B., Kamel, E., Gaber, K., Gouda, M., Abdelwahab, M., Kamel, M., Nasry, M., Ayad, M., Talkan, M., Abulhamd, O., Abdelsalam, S., Bedeer, S., Yaseen, T., Abdelaziz, Y., Yousef, Y., Elshaer, S. (2024). Impact of carotenoids on ulcerative colitis induced colorectal cancer - A review. EKB Journal Management System, (), 1-10. doi: 10.21608/ijhr.2024.274027.1001

Tohada M. AL-Noshokaty; Nourhan M. Abdelmaksoud; Ahmed I. Abulsoud; Ahmed A. Ahmed; Alaa A. Elsawy; Amira G. Elsayed; Antonios T. Shihata; Anton V. Bakhom; Ashraqat M. Hassan; Aya G. Badawy; Aya M. Elsayed; Basanty M. Louis; Eman M. Kamel; Kholoud S. Gaber; Malak A. Gouda; Manar E. Abdelwahab; Marina A. Kamel; Mina G. Nasry; Mera N. Ayad; Mohamed A. Talkan; Omnia S. Abulhamd; Samaa H. Abdelsalam; Seham M. Bedeer; Tasneem G. Yaseen; Yara I Abdelaziz; Youstena A. Yousef; Shereen S Elshaer. "Impact of carotenoids on ulcerative colitis induced colorectal cancer - A review". EKB Journal Management System, , , 2024, 1-10. doi: 10.21608/ijhr.2024.274027.1001

AL-Noshokaty, T., Abdelmaksoud, N., Abulsoud, A., Ahmed, A., Elsawy, A., Elsayed, A., Shihata, A., Bakhom, A., Hassan, A., Badawy, A., Elsayed, A., Louis, B., Kamel, E., Gaber, K., Gouda, M., Abdelwahab, M., Kamel, M., Nasry, M., Ayad, M., Talkan, M., Abulhamd, O., Abdelsalam, S., Bedeer, S., Yaseen, T., Abdelaziz, Y., Yousef, Y., Elshaer, S. (2024). 'Impact of carotenoids on ulcerative colitis induced colorectal cancer - A review', EKB Journal Management System, (), pp. 1-10. doi: 10.21608/ijhr.2024.274027.1001

AL-Noshokaty, T., Abdelmaksoud, N., Abulsoud, A., Ahmed, A., Elsawy, A., Elsayed, A., Shihata, A., Bakhom, A., Hassan, A., Badawy, A., Elsayed, A., Louis, B., Kamel, E., Gaber, K., Gouda, M., Abdelwahab, M., Kamel, M., Nasry, M., Ayad, M., Talkan, M., Abulhamd, O., Abdelsalam, S., Bedeer, S., Yaseen, T., Abdelaziz, Y., Yousef, Y., Elshaer, S. Impact of carotenoids on ulcerative colitis induced colorectal cancer - A review. EKB Journal Management System, 2024; (): 1-10. doi: 10.21608/ijhr.2024.274027.1001

	Impact of carotenoids on ulcerative colitis induced colorectal cancer - A review
International Journal for Holistic Research
Articles in Press, Accepted Manuscript, Available Online from 10 June 2024 PDF (2.51 M)
Document Type: Review articles
DOI: 10.21608/ijhr.2024.274027.1001
Authors
Tohada M. AL-Noshokaty^* ¹; Nourhan M. Abdelmaksoud¹; Ahmed I. Abulsoud²; Ahmed A. Ahmed¹; Alaa A. Elsawy¹; Amira G. Elsayed¹; Antonios T. Shihata¹; Anton V. Bakhom¹; Ashraqat M. Hassan¹; Aya G. Badawy¹; Aya M. Elsayed¹; Basanty M. Louis¹; Eman M. Kamel¹; Kholoud S. Gaber¹; Malak A. Gouda¹; Manar E. Abdelwahab¹; Marina A. Kamel¹; Mina G. Nasry¹; Mera N. Ayad¹; Mohamed A. Talkan¹; Omnia S. Abulhamd¹; Samaa H. Abdelsalam¹; Seham M. Bedeer¹; Tasneem G. Yaseen¹; Yara I Abdelaziz¹; Youstena A. Yousef¹; Shereen S Elshaer³
¹Department of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt
²1- Department of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt 2- Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City 11231, Cairo, Egypt
³1-Biochemistry Department, Faculty of Pharmacy, Heliopolis University, Cairo, Egypt 2-Department of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt
Abstract
Ulcerative colitis (UC) is one of the major forms of irritable bowel disease that is characterized by chronic inflammation of the colon and may progress into colorectal cancer (CRC), which is the second most deadly cancer all in the world. Some inflammatory mediators like tumor necrosis factor alpha (TNFα) increases resulting in a repeated cycle of inflammation leading to UC. Chronic inflammation found in CRC is believed to be due to induction of cytokines (as T cells and macrophage) and chemokines leading to alterations in proliferation, survival, and migration of epithelial cells. Particularly, inflammatory signaling pathways such as NF-κB, IL-6/ Signal transducer and activator of transcription 3 (STAT3), cyclooxygenase-2 (COX-2) / prostaglandin (PGE2), and IL-23/ Th17 have been identified in the propagation of UC related CRC and non-colitis related CRC. UC induced CRC is treated with anti-inflammatory drugs but may be associated with side effects. Therefore, carotenoids as natural drugs are used recently for the treatment of UC and CRC.
Keywords
Carotenoids; Natural anti-inflammatory; Ulcerative colitis; Colo rectal cancer

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