Association of angiotensin-converting enzyme gene polymorphism and clinical characteristics in Egyptian patients with major depressive disorder | ||
| Egyptian Journal of Psychiatry | ||
| Volume 42, Issue 2, July 2021 PDF (434.59 K) | ||
| DOI: 10.4103/ejpsy.ejpsy_49_20 | ||
| Authors | ||
| Adel ElMissiry; Fatma A. Abuzahra; Marwa ElMissiry; Eman Shorub; Reem Hashim; Dalia A.M. Mahmoud | ||
| Abstract | ||
| Objectives Depression is one of the leading causes of disability and suicide worldwide. It has strong genetic etiopathogenesis, especially that related to angiotensin-converting enzyme (ACE) gene polymorphism. Therefore, this research tackled the relation between genetic variants of ACE polymorphism and symptomatology profile of major depression. Patients and methods A total of 42 patients diagnosed with depression matched with 39 controls underwent Structured Clinical Interview for the DSM-IV Axis I diagnosis clinician version, Structured Clinical Interview for the DSM-IV Axis I diagnosis-nonpatient edition, Hamilton Depression Rating Scale, real-time PCR for genotyping, and serum cortisol level assay. Results ACE I/D gene polymorphism was significantly higher in patients with major depression (45.2%) compared with the control group (25.6%). Patients with I/D polymorphism showed longer duration of illness; greater severity; higher number of episodes and rate of hospitalization; higher tendency to be prescribed serotonin/norepinephrine reuptake inhibitors and to receive electroconvulsive therapy; higher scores of core depressive symptoms, such as guilt feeling, inability to work, and suicidal ideation; and higher serum cortisol level than the other genotype groups. Conclusion Our findings support the notion that ACE I/D polymorphism affects major depression severity and symptomatology imprint. | ||
| Keywords | ||
| Angiotensin-converting enzyme; Cortisol; Gene; major depressive disorders; Polymorphism | ||
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