Oxidative Stress Increases Activin A Secretion in Pregnancy Hypertensive States
Salem, D., Obaia, E., Abd El Aziz, G., El Abedeen, E. (2011). Oxidative Stress Increases Activin A Secretion in Pregnancy Hypertensive States. EKB Journal Management System, 31(1), 195-210. doi: 10.21608/besps.2011.35981
Dawlat Salem; Eman Obaia; Ghada Abd El Aziz; Eman El Abedeen. "Oxidative Stress Increases Activin A Secretion in Pregnancy Hypertensive States". EKB Journal Management System, 31, 1, 2011, 195-210. doi: 10.21608/besps.2011.35981
Salem, D., Obaia, E., Abd El Aziz, G., El Abedeen, E. (2011). 'Oxidative Stress Increases Activin A Secretion in Pregnancy Hypertensive States', EKB Journal Management System, 31(1), pp. 195-210. doi: 10.21608/besps.2011.35981
Salem, D., Obaia, E., Abd El Aziz, G., El Abedeen, E. Oxidative Stress Increases Activin A Secretion in Pregnancy Hypertensive States. EKB Journal Management System, 2011; 31(1): 195-210. doi: 10.21608/besps.2011.35981

Oxidative Stress Increases Activin A Secretion in Pregnancy Hypertensive States

Bulletin of Egyptian Society for Physiological Sciences
Article 14, Volume 31, Issue 1, December 2011, Pages 195-210    PDF (246.97 K)
Document Type: Original Article
DOI: 10.21608/besps.2011.35981
Authors
Dawlat Salem* 1; Eman Obaia1; Ghada Abd El Aziz2; Eman El Abedeen3
1Department of Medical Biochemistry, Cairo University
2Department of Medical Biochemistry, Beni Suef University
3Department of Gynaecology and Obstetric, Beni Suef University
Abstract
Introduction: Activin A is a glycoprotein hormone produced by many tissues. During
normal pregnancy the fetoplacental unit is the main source of activin A with the
placenta producing the majority of secreted activin A. Oxidative stress may be the
underlying mechanism for increased placental activin A production in preeclampsia.
Aim of Work: To evaluate the levels of activin A and malondialdehyde (MDA) in
pregnancy hypertensive states and to explore whether circulating levels of activin A
are correlated to MDA levels (marker of oxidative stress). Subjects and Methods:
The study included 75 pregnant women divided into three groups: 25 pregnant
women with normal blood pressure (group1 as control), 25 pregnant women with
pregnancy induced hypertension (PIH) (groupII) and 25 pregnant women with
preeclampsia (groupIII). Serm levels of activin A and malondialdehyde (MDA) were
measured by ELISA and by colorimetric methods respectively. Results: Serum levels
of activin A and malondialdehyde were higher in patients with preeclampsia than in
patients with pregnancy induced hypertension and that of control group. There was a
highly significant correlation between serum levels of activin A and each of
malondialdehyde and blood pressure in preeclampsia group and PIH group.
Conclusion: Serum levels of activin A might be used as a marker that reflects the
severity of pregnancy hypertensive states. Oxidative stress might be the mechanism of
increased secretion of activin A.
Keywords
preeclampsia; Oxidative Stress; Activin A
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