COMPARATIVE STUDY AMONG THREE MANIPULATING RATIO SPECTRA METHODS FOR THE DETERMINATION OF MOLNUPIRAVIR IN PRESENCE OF ITS ACID-INDUCED DEGRADATION PRODUCT | ||
| Al-Azhar Journal of Pharmaceutical Sciences | ||
| Volume 69, Issue 1, March 2024, Pages 130-151 PDF (1.83 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ajps.2024.360414 | ||
| Authors | ||
| Mohamed Wafaa Nassar1; Ashraf Abdelfatah2; Ahmed W Madkor3; Mohamed A Abdelaziz* 4 | ||
| 1Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy (Boys), Al-Azhar University,11751, Nasr City, Cairo, Egypt | ||
| 21Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy (Boys), Al-Azhar University,11751, Nasr City, Cairo, Egypt | ||
| 3Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy (Boys), Al-Azhar University,11751, Nasr City, Cairo, Egypt. | ||
| 4Armed Forces Collage Of Medicine Hospital (AFCMH),Military Medical Academy (MMA) Cairo, Egypt | ||
| Abstract | ||
| The main purpose of this work is to establish three simple, sensitive, accurate and precise spectrophotometric methods manipulating ratio spectra for determination of molnupiravir in bulk powder and in pharmaceutical preparation in the presence of its acid-induced degradation product. Ratio derivative, ratio difference and mean centering of ratio spectra are simple, rapid and selective methods using manipulation of ratio spectra for the determination of components having overlapping spectra. The suggested methods were validated in compliance with the ICH guidelines and were successfully applied for determination of molnupiravir in bulk powder and in pharmaceutical preparation in the presence of its acid-induced degradation product. | ||
| Keywords | ||
| UV–VIS; Spectrophotometry; Ratio derivative; Ratio difference; Mean centering; Acid-induced degradation product; Molnuprivir | ||
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