Diagnostic Utility of Aquaporin-4 blood level in Neonatal Hypoxic Ischemic Encephalopathy | ||||
| International Journal of Applied Biochemistry and Molecular Biology | ||||
| Volume 1, Issue 2, June 2024, Page 26-50 PDF (352.7 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ijabmb.2024.360813 | ||||
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| Authors | ||||
| Dalia Saber Morgan1; Hend Abdel Aziz Taha Masoud* 2; Shaimaa Ali Abdelkareem3; Mohamed Adel Abdel Tawab1 | ||||
| 1Pediatrics department, Faculty of Medicine, Beni-Suef University, Beni-Suef 62511, Egypt. | ||||
| 2Pediatrics department, Beni-Suef general hospital, Beni-Suef University, Beni-Suef 62511, Egypt. | ||||
| 3Clinical and chemical pathology department, Faculty of Medicine, Beni-Suef University, Beni-Suef 62511, Egypt. | ||||
| Abstract | ||||
| Background: hypoxic-ischemic encephalopathy is one of the most important diseases in neonates. Objective: to evaluate the use of the blood level of aquaporin-4 in the diagnosis of hypoxic ischemic encephalopathy in neonates, and to determine the severity of hypoxia. Patients and Methods: a case-control study, was carried out on 40 hypoxic neonates, sample (1) at the age of 2 days while sample (2) at the age of (7) days, and 40 samples from a healthy control. The collected blood samples were used to measure the aquaporin-4 level. A clinical neurological examination was done to detect patients with HIE. Results: there was a statistically significant higher increase of AQP4 in cases than controls and a significant increase of it from the 2nd day to the 7th day, all cases had delayed crying after birth and most of them were hypotonic and most of them had convulsions, most of the cases had convulsions highly significant correlation between Aquaporin 4 level and the severity of ischemic hypoxic encephalopathy in neonates either at 2 or 7 days of age. Conclusion: it is found that hypoxia leads to an increase in serum Aquaporin-4 level, serum Aquaporin-4 level could be used as an early predictor in the diagnosis of hypoxic-ischemic encephalopathy, and serum Aquaporin-4 level in differentiation between grades of hypoxia gives us better sensitivity and specificity. | ||||
| Keywords | ||||
| Aquaporin-4; Hypoxia; Neonates; Encephalopathy; Ischemia | ||||
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