Biological and Histopathological Impacts of Titanium Dioxide Nanoparticles on the Freshwater Clam, Caelatura nilotica, and the Role of Dimercaptosuccinic acid | ||||
| Egyptian Journal of Aquatic Biology and Fisheries | ||||
| Article 56, Volume 28, Issue 3, May and June 2024, Page 967-984 PDF (1.66 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejabf.2024.361116 | ||||
 View on SCiNiTO | ||||
| Author | ||||
| AbdElhafez R. AbdElhafez et al. | ||||
| Abstract | ||||
| Given the widespread application of nanomaterials in various domains, Titanium Dioxidetitanium dioxide nanoparticles (TiO2 NPs) emerge as a potential ecological concern for aquatic ecosystems. This study aimed to investigate the impact of TiO2 NPs on the morphometrics, biometrics, and the histological structure of the digestive gland of the Caelatura nilotica clams, alongside the potential ameliorative effects of the dDimercaptosuccinic acid (DMSA). Clams were continuously exposed to variable concentrations of TiO2 NPs (25 and 150 µg/150µg/L) and DMSA (200 µg/200µg/L) for 4 weeks. The results revealed a significant increase in body length, width, height, shell, flesh, and total body weights in response toTiO2 NPs exposure at the end of the experiment. Histological examination of the digestive gland indicated notable changes, including necrosis, and fibrous tissue formation. Ultrastructural abnormalities includedwere irregularly shaped and detached secretory and digestive cells. Also,Additionally, there wasdamage to some organelles was detected like, such as Golgi bodies, and disrupted chromatin condensation inside the nuclei of those groups. However, DMSA administration showsshowed a promised mitigation of the adverse effects of TiO2 NPs, leading to a reduction of the metal accumulation and histological improvements. This study underscoresunderscored the potential use of C. nilotica as a model for assessingTiO2 NPs toxicity and highlightshighlighted the role of DMSA as a potential therapeutic intervention against nanoparticles induced toxicity. | ||||
| Keywords | ||||
| Caelatura nilotica; DMSA; Biometrics; Bivalves; Digestive gland | ||||
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