Importance of Serum Il-8 and Rantes as Markers for Breast Cancer Progression | ||||
| Bulletin of Egyptian Society for Physiological Sciences | ||||
| Article 18, Volume 31, Issue 2, June 2011, Page 241-250 PDF (174.67 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/besps.2011.36144 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Maathir El Shafie* 1; Mohamed Megahed2; Ayman El-Batanony3; Mohamed Shehata4 | ||||
| 1Medical Biochemistry Department, Faculty of Medicine, Menoufiya University | ||||
| 2Plastic Surgery Department, Faculty of Medicine, Menoufiya University | ||||
| 3General Surgery Department, Faculty of Medicine, Menoufiya University | ||||
| 4Oncology Department, Faculty of Medicine, Menoufiya University | ||||
| Abstract | ||||
| Breast cancer is one of the most feared human illnesses. RANTES (regulated upon activation normal T cells expressed and secreted), is a chemokine which is produced by several tumor cells including breast cancer cells. IL-8 is a member of the CXC chemokine family. A tumor promoting role of IL-8 has been proposed in a wide variety of human solid tumors including breast cancer. The aim of the present work is to estimate levels of RANTES and IL-8 in breast cancer patients with and without distant metastasis and to correlate their levels in liver and other organs with metastasis to those without metastasis and healthy controls. The study was carried out on 70 subjects, they were divided into 3 groups: group A (25 breast cancer patients without distant metastasis), group B (25 breast cancer patients with distant metastasis) and group C (20 healthy controls). All subjects were submitted to full history taking, clinical, radiological examinations and measurements of serum RANTES and IL-8. Regarding RANTES, the results showed, a significant difference between control group and group A and also between control group and group B (P< 0.001), while there was no significant difference between group A and group B (P>0.05). In group A and B, RANTES showed no significant difference between those with loco regional lymph nodes and liver metastasis when compared with those without loco regional lymph nodes and liver metastasis respectively. On the other hand, IL-8 showed a significant difference between control group and group A, between control group and group B and also between group A and group B (P<0.001). In group B, the mean value of IL-8 among those with liver metastasis was significantly higher than those without liver metastasis. Similarly, in group A, in patients with loco regional lymph nodes metastasis when compared to patients without loco regional lymph node metastasis. Conclusion: IL-8 may be a useful marker in monitoring metastatic breast cancer and with other tumor markers as CEA and CA15-3 it can be a useful indicator of metastatic breast cancer, while RANTES can't be used in monitoring breast cancer progression and degree of metastasis, possibly because of its increase in other malignancies and inflammatory diseases. | ||||
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