Bcl2 and c-erbB-3 as Prognostic Markers of Hepatocellular Carcinoma | ||
| Bulletin of Egyptian Society for Physiological Sciences | ||
| Article 19, Volume 30, Issue 1, December 2010, Pages 301-310 PDF (247.73 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/besps.2010.36180 | ||
| Authors | ||
| Hanan Fouad* 1; Ahmed Eldemery2 | ||
| 1Medical Biochemistry Department, Faculty of Medicine, Cairo University | ||
| 2Biochemistry Department, Faculty of Medicine, October 6 University | ||
| Abstract | ||
| The present study was conducted to evaluate gene expression profile of c-erbB-3 and bcl2 in hepatocellular carcinoma patients (HCC) with and without associated hepatitis C virus (HCV) infection. Forty eight subjects were included in the study and divided equally into 2 groups: Group 1 involved HCC subjects with associated HCV infection and group 2 involved HCC subjects without HCV associated infection. Adjacent para-cancerous tissues were examined as control samples. Correlations with various clinico-pathological parameters of the tumor were assessed; stage, tumor size, intra-hepatic metastasis and carcinoma differentiation. c-erbB-3 oncogene was expressed in 83.33% (40/48) of total HCC samples and in 31.25% (15/48) of the noncancerous lesions. c-erbB-3 was expressed in 87.5% (21/24) of HCC samples with associated HCV infection and in 79.16% (19/24) of HCC without associated HCV infection. Gene expression of c-erbB-3 was significantly correlated to the clinico-pathological parameters of the tumor. As regards bcl2 gene expression, the gene was expressed in 20.8% (10/48) of total HCC samples and in the paracancerous lesions. Bcl2 was expressed in 20.8% (5/24) of HCC samples with and without HCV associated infection. Gene expression of bcl2 did not show significant correlations to the clinico-pathological parameters of the tumor. In conclusion, expression profile of c-erbB-3 in hepatocellular carcinoma patients could be used as a prognostic molecular marker in HCC. | ||
| Keywords | ||
| Hepatocellular carcinoma; Bcl2; c-erbB-3 | ||
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