Carbapenem-resistant Klebsiella pneumoniae in COVID-19 patients admitted to intensive care units of Zagazig University Hospitals

Ahmed, Tahia Mohamed; A. Afifi, Samir; M. Hassaneen, Ahmad; Radwan, Mona; Ateya, Rehab Mohamed

doi:10.21608/mid.2024.277993.1853

	Carbapenem-resistant Klebsiella pneumoniae in COVID-19 patients admitted to intensive care units of Zagazig University Hospitals
Microbes and Infectious Diseases
Article 1, Volume 5, Issue 4, November 2024, Page 1240-1252 PDF (623.22 K)
Document Type: Original Article
DOI: 10.21608/mid.2024.277993.1853
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Authors
Tahia Mohamed Ahmed ¹; Samir A. Afifi²; Ahmad M. Hassaneen¹; Mona Radwan³; Rehab Mohamed Ateya¹
¹Department of Clinical Pathology , Faculty of Medicine, Zagazig University, Egypt
²Internal Medicine, Faculty of Medicine, Zagazig University, Egypt
³Department of community and occupational medicine, Faculty of Medicine, Zagazig University, Egypt
Abstract
Background: Continuous monitoring is crucial to detect infection by Carbapenemase-producing Klebsiella pneumoniae (CPKP) in intensive care COVID-19 patients. Aim: to evaluate the CR-KP colonization and co- infection and evaluate the antibiotic resistance pattern. Methods: A cross -sectional study was done on COVID-19 patients with CPKP infection in Zagazig University Hospitals where rectal swab samples were detected using XpertCarba-R Assay(Cepheid, Sunnyvale), while isolates from sputum, urine, and blood culture were identified phenotypically by VITEK® 2 (bioMérieux SA) and modified Hodge test while genotypically by XpertCarba-R Assay(Cepheid, Sunnyvale). Results: CPKP was found in 60 patients out of 140 patients (42.8%), with 34 CPKP identified from rectal swabs, 12 patients infected from diverse locations (blood, respiratory secretions, and urine), and 14 COVID-19 patients developing CPKP co-infection with colonization. A widespread resistance to all antibiotic classes was found on the antibiograms of CPKP isolates and the blaNDM was the most common genotype detected by preliminary PCR testing. Conclusion: Regarding CPKP infection, a continues focus should be taken when dealing with it, particularly among COVID-19 patients. The incidence of multi-drug resistance due to nosocomial infection can be decreased by the rigorous monitoring of colonized patients and expedite the infection control practices.
Keywords
COVID-19; carbapenemase; colonization


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