Association of Plasma Sialic Acid concentrations with Diabetic Nephropathy in Syrian Individuals with Type 2 Diabetes Mellitus | ||||
| Zagazig Journal of Pharmaceutical Sciences | ||||
| Volume 33, Issue 1, June 2024, Page 49-56 PDF (525.25 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zjps.2024.249752.1055 | ||||
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| Authors | ||||
Asmaa Adel Badrah   1; Raghda Lahdo2; Rafah Manafikhi 3; Samer Haj Kaddour4
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| 1Department of Biochemistry and Microbiology, Faculty of Pharmacy, University of Aleppo, Aleppo, Syria. | ||||
| 2Department of of Biochemistry and Microbiology, Faculty of Pharmacy, University of Aleppo, Al-Wataniya Private University, Hama, Syria. | ||||
| 3Department of Biochemistry and Microbiology, Faculty of Pharmacy, University of Aleppo, Syria. | ||||
| 4Department of Laboratory Medicine, Faculty of Medicine, University of Aleppo, Syria. | ||||
| Abstract | ||||
| Background: Type 2 Diabetes Mellitus (T2DM) is a significant global health issue, often leading to microvascular complications such as Diabetic Nephropathy, a major cause of chronic kidney disease. The objective of this research was to assess the association between plasma Sialic Acid (SA) levels and C-Reactive Protein (CRP), along with other laboratory indicators of the Diabetic Nephropathy in Syrian patients. Materials and Methods: The research conducted from 2022 to 2023, involved 115 participants divided into 3 groups: 33 T2DM patients without complications, 52 with Diabetic Nephropathy, and 30 healthy controls. Parameters like Plasma Glucose, Urea, Creatinine, C-Reactive Protein (CRP), and Urine Microalbumin were measured using spectrophotometry. SA levels were determined using Ehrlich’s method, and eGFR was calculated using the Cockcroft–Gault formula. Results: T2DM patients, especially those with Nephropathy, showed significant increases in plasma Glucose, SA, CRP, Creatinine, Urea, and Urine Microalbumin compared to controls. A positive correlation was observed between SA levels and these parameters, with a notable negative correlation with eGFR. Conclusion: Plasma SA levels are significantly elevated in T2DM patients with Nephropathy and show a positive association with CRP levels. These findings suggest that SA could be a potential biomarker for Diabetic Nephropathy, offering a predictive tool for early diagnosis and preventive strategies for managing this complication. | ||||
| Keywords | ||||
| Sialic Acid; C-Reactive Protein; Diabetic Nephropathy; Type 2 Diabetes Mellitus; Urine Microalbumin | ||||
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