MAGE-3 And -4 Genes as Possible Markers for Early Detection of Metastases in HCV Egyptian Patients Complicated By HCC
Hussein, Y., Gharib, A., Mohamed, R., Radwan, M., Elsawy, W. (2010). MAGE-3 And -4 Genes as Possible Markers for Early Detection of Metastases in HCV Egyptian Patients Complicated By HCC. EKB Journal Management System, 30(2), 245-254. doi: 10.21608/besps.2010.36311
Yousri Hussein; Amal Gharib; Randa Mohamed; Mohamed Radwan; Wael Elsawy. "MAGE-3 And -4 Genes as Possible Markers for Early Detection of Metastases in HCV Egyptian Patients Complicated By HCC". EKB Journal Management System, 30, 2, 2010, 245-254. doi: 10.21608/besps.2010.36311
Hussein, Y., Gharib, A., Mohamed, R., Radwan, M., Elsawy, W. (2010). 'MAGE-3 And -4 Genes as Possible Markers for Early Detection of Metastases in HCV Egyptian Patients Complicated By HCC', EKB Journal Management System, 30(2), pp. 245-254. doi: 10.21608/besps.2010.36311
Hussein, Y., Gharib, A., Mohamed, R., Radwan, M., Elsawy, W. MAGE-3 And -4 Genes as Possible Markers for Early Detection of Metastases in HCV Egyptian Patients Complicated By HCC. EKB Journal Management System, 2010; 30(2): 245-254. doi: 10.21608/besps.2010.36311

MAGE-3 And -4 Genes as Possible Markers for Early Detection of Metastases in HCV Egyptian Patients Complicated By HCC

Bulletin of Egyptian Society for Physiological Sciences
Article 15, Volume 30, Issue 2, June 2010, Page 245-254  XML PDF (167.09 K)
Document Type: Original Article
DOI: 10.21608/besps.2010.36311
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Authors
Yousri Hussein* 1; Amal Gharib1; Randa Mohamed1; Mohamed Radwan2; Wael Elsawy3
1Medical biochemistry Department, Faculty of Medicine, Zagazig University
2Tropical Medicine Department, Faculty of Medicine, Zagazig University
3Clinical oncology and Nuclear Medicine Department, Faculty of Medicine, Zagazig University
Abstract
The dissemination of hepatocellular carcinoma (HCC) cells into the circulation plays
a critical role in postoperative recurrence and metastasis. Early detection of
metastatic tumor cells is critical to identify HCC patients at high risk of relapse.
MAGE-3 and -4 genes were evaluated by reverse transcription polymerase chain
reaction for the possibility of using them as new markers for early detection of
metastases in 160 HCV Egyptian patients, 115 of them were complicated with HCC.
The expression of MAGE-3 and MAGE-4 mRNA in peripheral blood of patients with
metastatic HCC, were 36 % and 52%, respectively. While the expression of MAGE-3
and MAGE-4 mRNA in peripheral blood of patients with localized HCC, were 12 %
and 16%, respectively. Moreover at least one type of MAGE-3 or MAGE-4 mRNA
was found in the peripheral blood of 68% of the metastatic HCC patients and in 20%
of the localized HCC patients. While neither the controls nor the cirrhotic patients
show expression of MAGE-4 mRNA in their peripheral blood. MAGE-3 and MAGE-4
may be a promising diagnostic tool for monitoring the prognosis of HCC patients and
early detection of occult hematogenous metastasis of HCC.
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