Antiaging and Skin Whitening Potentials of a Galloyl quinic Acid Derivative From Guiera senegalensis (J. F. Gmel.) Bark Extract: A Comparative In Vitro Investigation and Chemical Fingerprints for Different Extraction Techniques.

El-Sharawy, Reham T.; Hassanein, Heba D.; Radwan, Rasha A.; El-Taher, Eman M.; Kassem, Mona E. S.

doi:10.21608/ejchem.2024.294859.9798

	Antiaging and Skin Whitening Potentials of a Galloyl quinic Acid Derivative From Guiera senegalensis (J. F. Gmel.) Bark Extract: A Comparative In Vitro Investigation and Chemical Fingerprints for Different Extraction Techniques.
Egyptian Journal of Chemistry
Volume 68, Issue 2, February 2025, Page 507-513 PDF (243.29 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2024.294859.9798
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Authors
Reham T. El-Sharawy ¹; Heba D. Hassanein²; Rasha A. Radwan³; Eman M. El-Taher⁴; Mona E. S. Kassem¹
¹Phytochemistry and Plant Systematics Department, National Research Centre, 33 El-Bohouth St., Former ElTahrir St., P.O.12622, Dokki, Giza, Egypt.
²Chemistry of Medicinal Plants Department, National Research Centre, 33 El-Bohouth St., Former ElTahrir St., P.O.12622, Dokki, Giza, Egypt.
³Biochemistry Department, Faculty of Biotechnology, German International University, Regional Ring Rd, East Cairo, New Administrative Capital, Egypt.
⁴Department of Pharmacognosy, Faculty of Pharmacy, Egyptian Russian University, P.O. 63514, Badr City, Cairo, Egypt
Abstract
Aqueous alcoholic extracts from three different extraction procedures for Guiera senegalensis bark were analyzed both qualitatively for their chemical fingerprints using HPLC and quantitatively for their phenolic content using folin ciocalteu assay. A comprehensive phytochemical study was done on the extract with the largest phenolic content where five phenolic compounds were isolated and identified using conventional chemical methods and advanced spectroscopic techniques; the major compound (4) was identified as 3,4,5-tri-O-galloylquinic acid (UV, 1H-NMR and 13C-NMR). The extracts together with the major phenolic metabolite were subjected to an in vitro biochemical study for their enzyme inhibitory activities which confirmed the pure compound’s potential as a promising antiaging and skin whitening agent against tyrosinase (IC50 256 µg/ml), collagenase (IC50 385.6 µg/ml) and elastase (IC50 147.7 ug/ml)
Keywords
Guiera senegalensis; Phenolics; galloyl quinic acids; extraction techniques; tyrosinase; elastase; collagenase


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