A Canine model of carbon tetrachloride (Ccl4) induced liver cirrhosis: I. Clinical, hematological and biochemical Evaluations
Hassan, M., Hassan, E., El-Tookhy, O., Abdelfattah, S., Shehab, G., Shamaa, A. (2016). A Canine model of carbon tetrachloride (Ccl4) induced liver cirrhosis: I. Clinical, hematological and biochemical Evaluations. EKB Journal Management System, 62(1), 21-25. doi: 10.21608/vmjg.2016.363261
Marwa Hassan; Elham Hassan; Omar El-Tookhy; Sabry Abdelfattah; Gehan Shehab; Ashraf Shamaa. "A Canine model of carbon tetrachloride (Ccl4) induced liver cirrhosis: I. Clinical, hematological and biochemical Evaluations". EKB Journal Management System, 62, 1, 2016, 21-25. doi: 10.21608/vmjg.2016.363261
Hassan, M., Hassan, E., El-Tookhy, O., Abdelfattah, S., Shehab, G., Shamaa, A. (2016). 'A Canine model of carbon tetrachloride (Ccl4) induced liver cirrhosis: I. Clinical, hematological and biochemical Evaluations', EKB Journal Management System, 62(1), pp. 21-25. doi: 10.21608/vmjg.2016.363261
Hassan, M., Hassan, E., El-Tookhy, O., Abdelfattah, S., Shehab, G., Shamaa, A. A Canine model of carbon tetrachloride (Ccl4) induced liver cirrhosis: I. Clinical, hematological and biochemical Evaluations. EKB Journal Management System, 2016; 62(1): 21-25. doi: 10.21608/vmjg.2016.363261

A Canine model of carbon tetrachloride (Ccl4) induced liver cirrhosis: I. Clinical, hematological and biochemical Evaluations

Veterinary Medical Journal (Giza)
Volume 62, Issue 1, January 2016, Page 21-25  XML PDF (1.94 MB)
Document Type: Original Article
DOI: 10.21608/vmjg.2016.363261
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Authors
Marwa Hassan* 1; Elham Hassan1; Omar El-Tookhy1; Sabry Abdelfattah2; Gehan Shehab3; Ashraf Shamaa1
1Depart of Surgery, Anesthesiology and Radiology, Faculty of Vet Med, Cairo University, Egypt
2Depart of Med Biochemistry and Molecular Biology, Faculty of Mede, Cairo University, Egypt
3Depart of Pathology, Animal Health Research Institute, Ministry of Agriculture, Egypt
Abstract
The liver is a vital organ of vertebrates and plays a major role in metabolism in addition to other numerous functions in the living body, including regulation of glycogen storage, decomposition of red blood cells, plasma protein synthesis, hormone production, and detoxification. Damage of hepatic cells “Liver cirrhosis” is apotentially life-threatening condition. This could be accredited to a variety of pharmacological agents, viruses, alcohol abuse, autoimmune inflammation and exposure to metabolic metals such as iron, copper and other toxic substances. Carbon tetrachloride (CCl4)is a known highly hepatotoxic agent. This study aimed to assess the degree of liver cirrhosis through clinical and biochemical and hematological analysis after the administration of CCl4 in order to establish a canine model of liver cirrhosis for further research work. Eighteen skeletally mature mongrel dogs received weekly oral administration of CCl4. (ImI/kg 98%) for 16 weeks. Dogs were examined for symptoms of liver cirrhosis and the degree of cirrhosis was recorded through clinical and biochemical and hematological tests. Dogs were of clinical manifestation of liver insufficiency with abnormal hematological and biochemical tests values so we can conclude that, the levels of serum markers of the liver (liver biochemical tests) and other hematological parameters can be taken as a staging indicator of liver cirrhosis.
Keywords
dogs; CCl4; liver; cirrhosis; hematological and biochemical tests
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