Safety and efficacy of Clopidogrel versus Ticagrelor in treating Non-STEMI elderly patients | ||
| Benha Journal of Applied Sciences | ||
| Article 18, Volume 9, Issue 1, January 2024, Pages 147-150 PDF (299.89 K) | ||
| Document Type: Original Research Papers | ||
| DOI: 10.21608/bjas.2024.261902.1310 | ||
| Authors | ||
| Magdy Abdallah Ghareeb* 1; Osama Sanad Arafa2; Alshimaa Mohammed Sabry3; Safaa Salah Emam4; Hatem Ibrahim Helal5 | ||
| 1Cardiology Departement, Nasr City Health insurance hospital , Cairo , Egypt. | ||
| 2Professor of Cardiology Faculty of Medicine-Benha University | ||
| 3Assistant Professor of Cardiology Faculty of Medicine- Benha University | ||
| 4Lecturer of Cardiology Faculty of Medicine- Benha University | ||
| 5Consultant of Cardiology Health Insurance Hospitals | ||
| Abstract | ||
| Background: Acute coronary syndrome describes a wide range of clinical conditions that are caused by acute myocardial ischemia. A mismatch between myocardial oxygen demand and supply constitutes the fundamental pathology of ACS. An independent risk factor for major adverse events following acute coronary events, age is furthermore, being a significant risk factor for atherosclerotic cardiovascular disease. In order to prevent recurrent thrombotic events in patients with dual antiplatelet therapy non-ST-elevation acute coronary syndrome, comprising a P2Y12 inhibitor and aspirin is critically important. For their demonstrated anti-inflammatory effects in addition to their antithrombotic properties, antiplatelet medications have been utilised to improve clinical outcomes in patients with atherosclerotic cardiovascular diseases. Methodology: The study. The study included 200 elderly patients presenting with NSTEMI. They were categorized into two groups: group 1: 100 NSTEMI patients received clopidogre, and group 2: 100 NSTEMI patients received ticagrelor. Results: Patients who received clopidogrel demonstrated significantly lower minor bleeding (P = 0.011) and overall bleeding (P < 0.001). Additionally, major bleeding was reduced in participants who received clopidogrel than in patients who received ticagrelor but without statistical significance (P = 0.123). Insignificant differences were reported regarding stent thrombosis, stroke, myocardial infarction, CV death, urgent revascularization and transient ischemic attacks. Conclusion: As an alternative to ticagrelor, clopidogrel is beneficial for elderly patients. Without increasing ischemic risk, clopidogrel is associated with a significantly reduced risk of major and minor bleeding. | ||
| Keywords | ||
| Acute coronary syndrome; clopidogrel; elderly; ticagrelor | ||
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