Serum Fetuin-A and Mitral Annular Calcification As a New Predictors For Significant Coronary Artery Disease | ||||
| Bulletin of Egyptian Society for Physiological Sciences | ||||
| Article 15, Volume 29, Issue 1, June 2009, Page 183-198 PDF (310.7 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/besps.2009.36337 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Maha Hammoudah* 1; Zizi Saad2; Mohamed Elrawy2 | ||||
| 1Medical Biochemistry Department, Faculty of Medicine, Menoufiya University | ||||
| 2Cardiology Department, Faculty of Medicine, Zagazig University | ||||
| Abstract | ||||
| Mitral annular calcification has been shown to be associated with atherosclerosis, and is a predictor of cardiovascular events. Fetuin-A has recently been described as a serum-based inhibitor of calcification. The present study was designed to evaluate the predictive value of serum fetuin-A and mitral annular calcification in patients with suspected/ diagnosed coronary artery disease. We prospectively studied fifty four patients with suspected/diagnosed coronary artery disease without renal impairment or rheumatic valvular disease. The patients divided into 3 groups according to fetuin- A values. Group 1 low fetuin-A (32 patients). Group 2 normal fetuin-A (12 patients), group 3 fetuin-A high fetuin-A (10 patients). Full clinical examination, transthoracic echocardiography, coronary angiography, biochemical investigations offered to all patients and fetuin-A level measured using EDI human fetuin-A ELISA kit. The results of the current study showed a higher incidence of mitral annular calcification among group 1 (59.4%) in comparison to other groups, on other hand the same group had lower left ventricular ejection fraction percent and higher incidence of resting regional wall motion abnormalities. Angiography showed a higher prevalence of severe coronary artery disease in patients with mitral annular calcification than those without. Group 1 had, also higher prevalence of left main stenosis (43.1%vs 0%) P<0.05, and triple vessels disease (43.6%vs 13%) P<0.05. While the predictive ability of Mitral annular calcification in detection of significant coronary artery disease was highly significant P= 0.0001. There was significant negative correlation between fetuin-A and hsCRP p<0.01and LDL-c p<0.05. One of the main findings is the inverse association of serum fetuin-A concentration with Mitral annular calcification as well as strong predictive value of both to presence of significant coronary artery disease after multilogestic regression analysis. Conclusion: in symptomatic patients with suspected coronary artery disease, the presence of low fetuin-A level and mitral annular calcification, may be considered as independent predictors for the presence of significant obstructive coronary artery disease. | ||||
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