Pharmacological Interventions to Mitigate Immunodeficiency in Children with Congenital Heart Defects: A Review Article

Alsaadi, Sultan Owaid; Fagihi, Ahmed Hussain; Alfaifi, Abdulmajeed Yahya; Sayd, Abdullah Shoei; Juraybi, Adel Mohammed; Alshammari, Sheddi Rafaa Hamad; Alharbi, Salman Salem; Al Malki, Tahani Saleh Abdullah; Almutairi, Abrar Awadh; Aloteaby, Reem Haleel; Alqobaiey, Fatma Gameel; Alshibl, Abdullah Ibrahim; Khaleel, Huda Ibrahim Ali

doi:10.21608/ejchem.2024.297066.9850

	Pharmacological Interventions to Mitigate Immunodeficiency in Children with Congenital Heart Defects: A Review Article
Egyptian Journal of Chemistry
Volume 67, Issue 13, December 2024, Page 691-703 PDF (867.23 K)
Document Type: Review Articles
DOI: 10.21608/ejchem.2024.297066.9850
View on SCiNiTO
Authors
Sultan Owaid Alsaadi¹; Ahmed Hussain Fagihi²; Abdulmajeed Yahya Alfaifi²; Abdullah Shoei Sayd²; Adel Mohammed Juraybi¹; Sheddi Rafaa Hamad Alshammari³; Salman Salem Alharbi¹; Tahani Saleh Abdullah Al Malki¹; Abrar Awadh Almutairi¹; Reem Haleel Aloteaby¹; Fatma Gameel Alqobaiey¹; Abdullah Ibrahim Alshibl³; Huda Ibrahim Ali Khaleel⁴
¹Ministry of Health, Saudi Arabia
²Technical Pharmacy, Jazan University, Jazan, Saudi Arabia
³King Fahad Medical City, Riyadh, Ministry of Health, Saudi Arabia
⁴Pediatric Cardiology Consultant Pediatric Cardiologist, Heart Health Cardiac Center, King Saud Medical City, Saudi Arabia
Abstract
Background _ Heart failure (HF) is a multifaceted clinical illness caused by several primary and secondary factors, and it follows similar patterns of disease progression. It is associated with significant rates of mortality, morbidity, and financial burden. Heart failure (HF) in children is mostly caused by the presence of congenital heart disease (CHD), with varying risks depending on the exact type of abnormality. The current management and therapy for heart failure in children are derived on treatment strategies used in adults. Aim of Work – This review examines the etiology, epidemiology, and clinical presentations of heart failure (HF) in children with congenital heart disease (CHD). Additionally, it highlights the clinical, genetic, and molecular features that are shared or different between pediatric HF and adult HF. The aim of this study is to establish a structure for comprehending the constantly expanding genetic and molecular data within the complex context of comprehensive phenotyping. Methods – We conducted a comprehensive search of relevant terms in ProQuest, PubMed, Web of Science, Cochrane Library, Embase, and Scopus. We evaluate clinical and translational research investigations on heart failure in congenital heart disease, encompassing the analysis of genetic, transcriptomic, and epigenetic aspects. Results – The review presents the key findings from the evaluated research, including: • Etiology and epidemiology of heart failure in children with congenital heart disease • Clinical presentations and phenotypes of pediatric HF compared to adult HF • Genetic, transcriptomic, and epigenetic factors contributing to the development and progression of HF in CHD • Potential biomarkers and therapeutic targets identified through the molecular and genetic studies. Conclusion – The paper presents unresolved challenges in the field of pediatric heart failure associated with congenital heart disease and provides directions for future research. This review aims to enhance our understanding of the complex interplay between genetic, molecular, and clinical factors in the context of heart failure in children with congenital heart abnormalities
Keywords
Heart Failure; Impaired Ventricular Function; Congenital Heart Defect; Genetic Factors; Pediatric Population


Statistics Article View: 356 PDF Download: 568