Serum levels of tumor necrosis factor alpha and interferon alpha in COVID-19 patients and their correlations with disease severity.

Ibrahim, Shorouk Alaa eldeen; Essa, Basem ELsayed; khattab, mona adel; Ahmed, Ola Ibrahim

doi:10.21608/mid.2024.286615.1931

	Serum levels of tumor necrosis factor alpha and interferon alpha in COVID-19 patients and their correlations with disease severity.
Microbes and Infectious Diseases
Article 2, Volume 5, Issue 4, November 2024, Page 1253-1263 PDF (758.17 K)
Document Type: Original Article
DOI: 10.21608/mid.2024.286615.1931
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Authors
Shorouk Alaa eldeen Ibrahim ¹; Basem ELsayed Essa ²; mona adel khattab³; Ola Ibrahim Ahmed ³
¹Medical Microbiology and Immunology, Abbasia Fever hospital, Cairo, Egypt
²Tropical Medicine National Hepatology and Tropical Medicine Research Institute, Egypt
³Medical Microbiology and Immunology department Faculty of medicine Ain Shams University, Abbassia, Cairo, Egypt
Abstract
Background: By the end of 2019, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was revealed in China and led to a widespread global outbreak and posed a serious threat to public health. The pathophysiology of COVID-19 is heavily reliant on cytokines either beneficial like type I interferon (IFN), or harmful like tumour necrosis factor alpha (TNF-α), considering the so-called cytokine storm. Aim of the study: to assess serum levels of TNF-α & IFN-α in COVID-19 patients and their correlations with disease severity. This might add a new aspect in COVID-19 treatment either cytokine and/or anti-cytokine therapy. Methods: The current study was conducted on 60 patients diagnosed as COVID-19, divided into two groups ICU and non ICU (30 patients each) and 30 apparently healthy individuals. Serum levels of TNF-α and IFN-α were measured by ELISA. Results: There was a statistical significant difference between COVID-19 patients and control group as regards TNFα and INFα serum levels (P<0.001, P<0.001) respectively. Significant correlation between TNF -α, INF-α serum levels and patients outcome ( p =0.000, p =0.000) respectively. Conclusion: Serum level of TNF-α is significantly higher in COVID-19 patients compared to controls while serum level of INF α that is significantly higher in controls compared to COVID-19 patients. Their association with disease severity suggests that they can possibly serve as reliable biomarkers for monitoring disease activity and predicting severity and outcome in COVID-19.
Keywords
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Tumor necrosis factor alpha (TNF- α); Interferon type I (IFN )


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