Trace Elements and Minerals Status in Pediatric Onset Nephrotic Syndrome and Their Relation to Proteinuria: a multicenter cross-sectional study.
Ahmed, H., Sallam, D., Abdel-Aziz, M., Sayed, A., Mabrouk, A. (2024). Trace Elements and Minerals Status in Pediatric Onset Nephrotic Syndrome and Their Relation to Proteinuria: a multicenter cross-sectional study.. EKB Journal Management System, 19(1), 48-61. doi: 10.21608/geget.2024.364026
Heba Mostafa Ahmed; Dina Ebrahem Sallam; Manar Mahmoud Abdel-Aziz; Ahmed Reda Sayed; Amna Gouda Mabrouk. "Trace Elements and Minerals Status in Pediatric Onset Nephrotic Syndrome and Their Relation to Proteinuria: a multicenter cross-sectional study.". EKB Journal Management System, 19, 1, 2024, 48-61. doi: 10.21608/geget.2024.364026
Ahmed, H., Sallam, D., Abdel-Aziz, M., Sayed, A., Mabrouk, A. (2024). 'Trace Elements and Minerals Status in Pediatric Onset Nephrotic Syndrome and Their Relation to Proteinuria: a multicenter cross-sectional study.', EKB Journal Management System, 19(1), pp. 48-61. doi: 10.21608/geget.2024.364026
Ahmed, H., Sallam, D., Abdel-Aziz, M., Sayed, A., Mabrouk, A. Trace Elements and Minerals Status in Pediatric Onset Nephrotic Syndrome and Their Relation to Proteinuria: a multicenter cross-sectional study.. EKB Journal Management System, 2024; 19(1): 48-61. doi: 10.21608/geget.2024.364026

Trace Elements and Minerals Status in Pediatric Onset Nephrotic Syndrome and Their Relation to Proteinuria: a multicenter cross-sectional study.

GEGET
Volume 19, Issue 1, June 2024, Page 48-61  XML PDF (611.73 K)
Document Type: Original Article
DOI: 10.21608/geget.2024.364026
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Authors
Heba Mostafa Ahmed email orcid 1; Dina Ebrahem Sallamorcid 2; Manar Mahmoud Abdel-Aziz3; Ahmed Reda Sayed4; Amna Gouda Mabrouk1
1Department of Pediatrics, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt.
2Department of Pediatrics, Division of Nephrology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
3Department of Clinical and Chemical Pathology, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt.
4Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt.
Abstract
Introduction: Studies on the status of trace elements and minerals in pediatric patients with idiopathic nephrotic syndrome (INS) are lacking. 
Aim of the Study: To study trace element status in a cohort of children with INS and the relationship with INS activity to advise the need for monitoring & supplementation during the disease course.
Methods: Material and methods: We studied 191 children with INS and 105 healthy children as a control group from two pediatric nephrology centers. We divided them into two groups: 86 patients in the relapse group and 105 patients in the remission group. We measured the serum levels of Zinc (Zn), Copper (Cu), Selenium (Se), Manganese (Mn), Iron (Fe), Calcium (Ca), Phosphorus (P), and Magnesium (Mg) in all of them.
Results: Significantly lower serum levels of Zn, Cu, and Fe levels were observed in patients with active disease than in the other groups, without remarkable differences between the remission and control groups. Significantly lower serum Ca, Mg, and Se serum levels were in the active disease group than those in remission and lower in the two disease groups than in the controls. Serum Mn and P were significantly elevated in patients with activity compared to those in remission and higher in the two groups than in the controls. Significant correlations were found between proteinuria & the studied elements except for Mn.
Conclusion: Children with INS have low levels of Zn, Cu, Fe, Se, Ca & Mg, while high levels of P & Mn during proteinuria. Follow-up of mineral & trace elements in children with Nephrotic Syndrome may be recommended, especially in patients with prolonged proteinuria.
Keywords
Trace elements; minerals; nephrotic syndrome; children
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