Prevalence of activated protein c resistance due to factor v leiden mutation in egyptian patients with chronic nonthrombotic venous ulcer | ||
| The Egyptian Journal of Surgery | ||
| Volume 35, Issue 3, July 2016 PDF (219.44 K) | ||
| DOI: 10.4103/1110-1121.189433 | ||
| Authors | ||
| Khaled Elalfy; Hosam Roshdy; Mohammed Farag; Talal Amer; Ziad Tawheed; Mohammed A. Gaballah | ||
| Abstract | ||
| Background Chronic venous leg ulcers are major health problems with great financial burden on patients and health resources. They are either post-thrombotic or not. Factor V Leiden (FVL) mutation is the most commonly diagnosed inherited thrombophilia. The present study compared the prevalence of activated protein C resistance (APCR) due to FVL mutation in patients with chronic nonthrombotic venous ulcer with an age-matched and sex-matched control group. Patients and methods Over a period of 6 years, 64 patients with chronic venous (nonthrombotic) leg ulcers were compared with 64 controls regarding APCR and FVL mutation. Results In total, 17 patients out of 64 tested positive for APCR (26.6%) [15 of them (23.4%) were due to FVL mutation (13 heterozygous and two homozygous)], whereas among controls only four tested positive for APCR (6.25%), all of them due to FVL mutation (all were heterozygous). Conclusion Patients with chronic nonthrombotic venous ulcers had statistically significant prevalence of FVL mutation compared with age-matched and sex-matched controls. Our results (although with some limitations) showed that a special cohort of primary varicose veins with this thrombophilic abnormality needs further investigation to accurately elicit its possible role in their disease progression into venous ulcers. | ||
| Keywords | ||
| Factor V Leiden; Protein C; Venous Leg Ulcers | ||
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