In the prolonged human battle against colorectal cancer, could genotoxic be in the front line of the war? | ||
| The Egyptian Journal of Surgery | ||
| Article 51, Volume 41, Issue 3, July 2022 PDF (380.53 K) | ||
| DOI: 10.4103/ejs.ejs_173_22 | ||
| Authors | ||
| Shahinda Rezk; Fatma Alazabi; Ezzeldin Anwar; Amel El Sheredy; Gamal ElSawaf; Mohamed Selimah | ||
| Abstract | ||
| Objective To find an association between colorectal cancer (CRC) and genotoxic isolated from the human microbiota. Patients and methods A total of 150 patients (65 males and 85 females) were recruited from the surgical endoscopy unit in the Medical Research Institute Hospital, Alexandria, Egypt. They were divided into two groups: group I included 100 neoplastic patients (benign and malignant), and group II included 50 nonneoplastic patients. After DNA extraction, real-time PCR was performed to detect the presence of in strains. Result The number of males (57.4%) among patients with malignant neoplastic illness was higher than the number of females (42.6%). Overall, no statistical difference was observed between the studied groups regarding sex (=0.059). Malignant neoplastic diseases were more common in patients above 45 years. Old age in malignant patients showed a high statistical significance compared with nonmalignant patients (≤0.001). The was detected in colorectal biopsies using the gene as a surrogate marker of the whole island. The current study demonstrated that the prevalence of -positive was significantly higher in patients with malignant neoplastic disease than benign neoplastic and nonneoplastic ones (=0.002). Conclusion + may act as a tumor promoter for CRC and could be used as a predictive marker for CRC development. In addition, the molecular identification may be of a good value in decreasing missed lesions during conventional colonoscopy. | ||
| Keywords | ||
| colorectal cancer; genotoxic Escherichia coli; microbiota | ||
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