Controlled Release of Amoxicillin from Chitosan-Coated Poly(lactic-co-glycolic acid) Nanoparticles | ||||
| Egyptian Journal of Chemistry | ||||
| Volume 67, Issue 13, December 2024, Page 2161-2170 PDF (960.12 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2024.272390.9703 | ||||
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| Authors | ||||
Moshera Samy   ; Magdy M.H. Ayoub
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| Polymers and Pigments Department, National Research Centre, 33 El Bouhoth St., Dokki, Giza 12622, Egypt. | ||||
| Abstract | ||||
| In this study, amoxicillin (AMX) loaded into poly (lactic-co-glycolic acid) nanoparticles (PLGA NPs) were successfully prepared by double emulsion technique using polaxamer 188 as a nonionic surfactant. The prepared nanoparticles (NPs) were successfully coated with different molecular weights of chitosan (CS). AMX-loaded PLGA NPs were coated with CS in order to obtain controlled drug release and increase the bioavailability of AMX. The range of PLGANPs' entrapment efficiency (EE%) was determined to be between 74.39% and 85.63%. EE% showed a definite increase with increasing CS molecular weight. While TEM images revealed that the produced nanoparticles have a spherical form, CS-PLGANPs showed particles that were monodisperse and in the nanosize range. The zeta potential is changing from negative to positive. DSC, XRD, and FTIR confirmed AMX was fully encapsulated in PLGANPs and coated with CS. In vitro AMX release from CS-PLGANPs showed sustained release, although slower release was observed when using CS with a higher molecular weight. According to research on drug release kinetics, CS-PLGANPs released AMX in a diffusion-controlled manner. | ||||
| Keywords | ||||
| Amoxicillin; Chitosan; Double emulsion, PLGANPs, Sustained release | ||||
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