Correlation between serum estrogen level and endometrial histology in cases of fibroid uterus in peri-menopausal peroid | ||
| Benha Medical Journal | ||
| Article 614, Volume 41, Issue 4, July and August 2024, Pages 197-205 PDF (570.75 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bmfj.2024.259420.1992 | ||
| Authors | ||
| Wael Naeem* 1; Ahmed K.Abbas2; Labiba K.Elsayed3; Ahmed Goda Helal4; Heba Mohamed Khatab5; Omar K.Naser6; Ali A. Bendary7 | ||
| 1Department of obstetrics and gynecology .benha university | ||
| 2obstetrics & gynecology faculty of medicine Benha University | ||
| 3benha | ||
| 4Obstetrics&Gynecology Benha Faculty of medicine Benha University Egypt | ||
| 5obstetrics & Gynecology department Ahmed Maher teaching Hospital Cairo ,Egypt | ||
| 6obstetrics and gynecology department,Benha faculty of medicine,Benha university , Benha , Egypt | ||
| 7Lecturer at department of Obstetrics & Gynecology, Faculty of Medicine, Benha University, Benha. Egypt. | ||
| Abstract | ||
| Back ground: Uterine leiomyoma represent over 75% of the amiable tumors in ladies of conceptive age amass. Endometrium is a hormonally responsive tissue . The reaction of endometrium to incitement by endogenous or exogenous steroid hormones is unsurprising Endogenous reaction is an impression of the hypothalamic–pituitary-ovarian pathway. Aim of this study : to assess serum level of E2 and study endometrial histological changes in instances of fibroid uterus .Patients and methods: This study included forty ladies have symptomatic fibroid uterus. history was taken, general examination, ultrasound examination, measuring serum estradiol and endometrial biopsy was taken by D&C or hysterectomy sent for histopathological examination. Results : endometrial thickness was ˃10mm in 69.2% of premenopausal and ˃5mm in 83%of postmenopausal . endometrial hyperplasia is the commonest glandular endometrial change represent(37.5%) ,complex hyperplasia without atypia 5%,simple hyperplasia with atypia 5% and proliferative endometrium 22.5%of all review bunch . in premenopausal patients hyperplasia with atypia related with the most elevated E2 level ( 252,6 pg) , complex hyperplasia without atypia with E2 level (221.6 ±6.22 SD), hyperplasia without atypia with E2 level (184.84 ± 12,11SD) and in postmenopausal patients hyperplasia with atypia with E2 level (245.3 pg), hyperplasia without atypia (145.68 ±33.53 SD) .Conclusion : there is correlation between serum oestrogen level , histopathological changes of endometrium and symptomatic fibroid uterus at perimenopausal age . | ||
| Keywords | ||
| Estrogen; Endometrial histology; Fibroid; Peri-menopausal | ||
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