Role of Botulinum Toxin A (Botox) as a New Modality in Induced Rhematoid Arthritis Versus Corticosteroids in Adult Male Albino Rat | ||||
| Journal of Medical Histology | ||||
| Article 4, Volume 7, Issue 1, June 2023, Page 65-78 PDF (807.03 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jmh.2022.151071.1102 | ||||
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| Authors | ||||
Mohamed sonbol1; Marwa M Elsawy 2; ahamed M Desouky 1; Mohamed Mohamed Abdel Moaty  3
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| 1anatomy department, faculty of medicine, ain shams university | ||||
| 2anatomy department,faculty of medicine, ain shams university | ||||
| 3department of anatomy faculty of medicine Cairo University | ||||
| Abstract | ||||
| Introduction: Rheumatoid arthritis (RA) is defined as a chronic immune-mediated disease and the Botox is tried to be a new treatment. The aim of our work to compare the ameliorating actions of the peri-articular Botox as a new modality and the systematic corticosteroids on the rheumatoid arthritis in the adult albino rats. Materials and methods: Rats were randomly allocated into 5 weight-matched groups, each of 5 rats; Group 1: ten rats were divided into the negative control were left without any intervention and the positive control were injected intra-articularly with saline, Group 2 induced RA by injecting rats with Freund's Complete Adjuvant (CFA), Group 3 were injected with Botox together with CFA and Group 4 were injected with dexamethasone (DEX) with CFA. Results: the RA induced rats showed significant improvement histologically, biochemically and radiologically when given corticosteroids with mild amelioration when given Botox. Conclusion: we have concluded that the use of Botox and dexamethasone were effective therapies of the RA with the priority to dexamethasone in the management of the RA. | ||||
| Keywords | ||||
| Keywords: Rheumatoid; Arthritis; dexamethasone; Botox and knee | ||||
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