THE THERAPEUTIC EFFECT OF MESENCHYMAL STEM CELLS AND ALFACALCIDOL ON CISPLATIN INDUCED ACUTE NEPHROTOXICITY IN MALE ALBINO RATS. | ||||
| ALEXMED ePosters | ||||
| Article 1, Volume 6, Issue 3, July 2024, Page 12-13 | ||||
| Document Type: Preliminary preprint short reports of original research | ||||
| DOI: 10.21608/alexpo.2024.303220.1887 | ||||
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| Authors | ||||
Abdelghany Hassan Abdelghany1; Melad Naim Bushra Kelada2; Walaa Abdel Salam Ahmed Omar3; Marwa Mahmoud Abdel Aziz Mady1; Dina Saad Fahmy Dawood  1
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| 1Department of Human Anatomy and Embryology, Faculty of Medicine, Alexandria University. | ||||
| 2Department of Human Anatomy and Embryology, Faculty of Medicine, Alexandria University | ||||
| 3Department of histology and cell biology, Faculty of Medicine, Alexandria University. | ||||
| Abstract | ||||
| Acute kidney injury (AKI) refers to the rapid decline of renal function, typically resulting from toxic or ischemic insults due to chemotherapy, antibiotics, or infection-related shock. Notably, approximately one-third of patients undergoing cisplatin therapy develop AKI, predominantly due to the nephrotoxicity of cisplatin. Cisplatin, an anti-neoplastic agent used for various solid-organ cancers, has its use limited by nephrotoxicity, a significant adverse effect. Oxidative stress is a crucial mechanism underlying cisplatin-induced AKI, suggesting that antioxidants like vitamin D may mitigate these adverse effects. Stem cells, particularly bone marrow-derived mesenchymal stem cells (BM-MSCs), offer a promising therapeutic approach for renal repair. These undifferentiated cells possess considerable self-renewal and tissue generation capabilities. BM-MSCs can ameliorate renal functional deficits, tubular necrosis, and apoptosis while promoting tubular regeneration, likely through paracrine or endocrine mechanisms rather than direct engraftment. AIM OF THE WORK: The aim of the present work was to: • Study the histological and immunohistochemical changes in a rat model of cisplatin – induced acute nephrotoxicity. • Study the efficacy of BM -MSCs and alfacalcidol (ALFA) to treat cisplatin-induced acute nephrotoxicity in adult male albino rats. | ||||
| Keywords | ||||
| Acute kidney injury; cisplatin; mesenchymal stem cells; alfacalcidol | ||||
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