Assessing Structural Characterization Of Novel Nano Organometallic Complexes Against Divergent Microbes | ||||
| Egyptian Journal of Chemistry | ||||
| Volume 67, Issue 9, September 2024, Page 613-636 PDF (1.4 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2024.276694.9448 | ||||
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| Authors | ||||
Mohammed Mohammed Kaid   1; Abdou Saad El Tabl2; Moshira Mohamed Abd-El Wahed3; Reham Wagdy Farid1; Awatef Abd Elsalam Masoud4
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| 1Department of Chemistry, Faculty of Science, El-Menoufia University, Shebin El -Kom, Egypt | ||||
| 2DepDepartment of Chemistry, Faculty of Science, El-Menoufia University, Shebin El -Kom, Egyptartment of Chemistry, Faculty of Science, Menoufia University | ||||
| 3Department of Pathology, Faculty of Medicine, El-Menoufia University, Shebin El-Kom, Egypt | ||||
| 4Department of Chemistry, Faculty of Science, Tobruk University, Libya | ||||
| Abstract | ||||
| The escalating prevalence of multidrug resistance (MDR) worldwide has spurred a critical imperative to explore and innovate novel therapeutic modalities and potent antimicrobial agents. Amide Schiffbase ligands (referred to as H3L1 and H3L2) have emerged as promising candidates for combating a spectrum of pathogens including Gram-negative bacteria, Gram-positive bacteria, and certain antifungal strains, amid the scarcity of novel antibiotics. Concurrently, β-naphthylamide (PAβN), a peptidomimetic compound, has garnered attention as an efflux pump inhibitor (EPI) aimed at surmounting efflux-mediated multidrug resistance. In this investigation, the antibacterial efficacy of two Schiff base ligands synthesized through the condensation of (N-(2-amino phenyl)-2- hydroxybenzamide) with hydroxybenzaldehyde, and (N-(2-aminoethyl)-2-hydroxybenzamide) with hydroxybenzaldehyde, alongside their respective complexes [H3L1.Cu(OAc)2].2H2O, [H3L1CuCl2].2H2O, [H3L1Ag2(SO4)], [H3L1Hg(SO4)(H2O)]·2H2O, [H3L2Cu(OAc)2]·2H2O, and [H3L2CuCl2]·3H2O). The ligands and their complexes were characterized using elemental and spectroscopic techniques such as IR, UV-VIS, Mass Spectra, 1H-NMR and ESR measurements as well as Magnetism, Conductivity, Thermal Analyses (DTA and TGA) and Electronic microscope. The conductivity measurements confirmed non electrolytic in nature, however, The electron microscope data indicate that, the complexes were found in nano-form. ESR spectra for Cu(II) complexes showed axial type with d(x2-y2) ground state. The compounds were assessed individually against a spectrum of bacteria including Escherichia coli (ATCC:10536), Klebsiella pneumoniae (ATCC:10031), Staphylococcus aureus (ATCC:13565), Streptococcus mutans (ATCC:25175), and Candida albicans (ATCC:10231), encompassing antibiotic-susceptible strains. Preliminary results of minimum inhibition concentration (MIC) assays revealed notable antimicrobial activity exhibited by the complexes [H3L1.Cu(OAc)2].2H2O, [H3L1CuCl2].2H2O, [H3L1Ag2(SO4)], [H3L1Hg(SO4)(H2O)]·2H2O, [H3L2Cu(OAc)2]·2H2O, and [H3L2CuCl2]·3H2O) when compared to the ligands in isolation. Further analysis via fractional inhibitory concentration (FIC) indices demonstrated enhanced MIC values indicative of additive and synergistic effects upon combining Nano metal amide Schiff base complexes with H3L1 and H3L2. These findings underscore the therapeutic promise inherent in the combined utilization of these metal complexes. | ||||
| Keywords | ||||
| Hydroxy Schiff – bases; complexes; spectra; magnetism; Antimicrobial activity | ||||
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