The Prognostic Significance of ACLR and HALP Scores in Hepatocellular Carcinoma Patients Treated with Sorafenib | ||||
| Zagazig University Medical Journal | ||||
| Volume 30, Issue 6, September 2024, Page 2533-2542 PDF (912.23 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zumj.2024.295419.3431 | ||||
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| Authors | ||||
amralla abdelmoneem1; marwa shabana 2; Yara Naser Mohamed  3; Adel Bakry4
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| 1Professor of Medical Oncology, Faculty of Medicine, Zagazig University | ||||
| 2Assistant Professor of Clinical Pathology, Faculty of Medicine, Zagazig University | ||||
| 3Resident of Medical Oncology, Faculty of Medicine, Zagazig University | ||||
| 4Department of Medical Oncology, Faculty of Medicine, Zagazig University, Egypt | ||||
| Abstract | ||||
| Background: Sorafenib is the standard treatment for patients with hepatocellular carcinoma (HCC) with advanced stage disease. An accurate prediction model is important to ascertain the prognosis of HCC patients treated with sorafenib. Aim of the study: This study aimed to predict the outcome of HCC patients treated with sorafenib using ACLR and HALP scores. Subjects and methods: This Observational Retrospective Cohort Study was conducted on 110 Patients with HCC patients from January 2015 to December 2022 at Medical Oncology Department, Faculty of Medicine, Zagazig University. Results: HALP and ACLR score were significantly associated with treatment outcome among HCC patients treated with sorafenib. HALP was a predictor for treatment outcome among HCC patients treated with sorafenib at cut off point of 42.9 with sensitivity of 75.7% and specificity of 86.3%. ACLR was a predictor for treatment outcome among HCC patients treated with sorafenib at cut off point of 75.6 with sensitivity of 78.4% and specificity of 82.2%. High HALP score indicates better prognosis with a cut off of 42.9. Low ACLR indicates better prognosis with a cut of 75.6. Conclusion: Both HALP and ACLR scores can be used as valid prognostic scores for independently predicting the overall prognosis in HCC patients treated with Sorafenib. Having a low HALP score indicates worse prognosis, while, our results showed that the cut off for ACLR 75.6 .. but high and low score didn't show any significance in predicting the PFS or OS but they show significant sensitivity and specificity. | ||||
| Keywords | ||||
| hepatocellular carcinoma; sorafenib; prognostic significance | ||||
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