Long non-coding RNA HOTAIR as diagnostic marker in dermatological autoimmune diseases: A systematic review

Atta Allah, Emad Adel; Abd El-Rahman, Amal Talaat; Aboraia, Nesreen Mohamed Mahmoud; Elamir, Azza Mohamed

doi:10.21608/fumj.2024.265276.1310

	Long non-coding RNA HOTAIR as diagnostic marker in dermatological autoimmune diseases: A systematic review
Fayoum University Medical Journal
Volume 13, Issue 3, April 2024, Page 40-48 PDF (844.28 K)
Document Type: Full Length research Papers
DOI: 10.21608/fumj.2024.265276.1310
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Authors
Emad Adel Atta Allah ¹; Amal Talaat Abd El-Rahman²; Nesreen Mohamed Mahmoud Aboraia³; Azza Mohamed Elamir⁴
¹Dermatology and Andrology department Faculty of Medicine Fayoum University.
²Dermatology, Faculty of medicine, Minia University
³Assistant professor of dermatology , STDs and Andrology Faculty of medicine Fayoum university .
⁴medical biochemistry and molecular biology department, faculty of medicine, fayoum university
Abstract
Background: Damage to different organs is caused by aberrant responses from the innate and adaptive immune systems in autoimmune disorders, which encompass a variety of issues. The cause of autoimmune diseases is a very complex and poorly understood phenomenon. Patients and methods: Our search result contained original research from PubMed, Medline, and EMBASE. There were no review papers included. Studies must have published at least one lncRNA that they discovered through experimentation. Results: Psoriasis, alopecia areata, systemic sclerosis, and melanoma were among the autoimmune dermatological conditions that were mentioned. With the exception of alopecia areata, where expression was downregulated relative to control, HOTAIR expression was significantly higher in cases of autoimmune dermatological diseases than in the control group in all cases. Conclusion: We can conclude that the long non-coding RNA known as HOTAIR functions as a diagnostic marker for skin autoimmune diseases and it also might play a role in their pathogenesis.
Keywords
Long non-coding RNA; HOTAIR; Marker; Autoimmune diseases


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