Antibodies to HIV-1 specific antigens in HBV and HCV coinfected patients in Warri, Nigeria

Olaniyan, Mathew Folaranmi; Ajiboye, Kemi Felicia; Olaniyan, Tolulope Busayo; Odegbemi, Odekunle Bola

doi:10.21608/mid.2024.298120.2013

	Antibodies to HIV-1 specific antigens in HBV and HCV coinfected patients in Warri, Nigeria
Microbes and Infectious Diseases
Article 9, Volume 6, Issue 1, February 2025, Page 102-109 PDF (221.95 K)
Document Type: Original Article
DOI: 10.21608/mid.2024.298120.2013
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Authors
Mathew Folaranmi Olaniyan ¹; Kemi Felicia Ajiboye ²; Tolulope Busayo Olaniyan ¹; Odekunle Bola Odegbemi ¹^{, 3}
¹Medical Laboratory Department, Edo State University, Uzairue, Edo State, Nigeria
²Public Health Department, Torrens University, Adelaide, Australia
³Medical Laboratory Department, Nigerian Navy Hospital, Warri, Delta State, Nigeria
Abstract
Background: Human Immunodeficiency Virus (HIV), Hepatitis B Virus (HBV), and Hepatitis C Virus (HCV) are critical global public health issues, particularly in resource-limited settings like Warri, Nigeria, where healthcare systems face significant challenges. This study investigates the prevalence of antibodies to HIV-1-specific antigens in HBV and HCV-coinfected patients in Warri. Methods: Utilizing a cross-sectional design, 350 HIV-positive individuals were systematically sampled, and their blood samples were analyzed using ELISA and Western blot techniques. Results: Among the participants, 17.7% were coinfected with HBV and 10.9% with HCV. A high prevalence of antibodies to HIV-1 gp120, gp41, and p24 was observed, with no significant differences between the HBV and HCV coinfected groups (p > 0.05). Conclusion: These findings highlight the impact of HBV and HCV coinfections on the humoral immune response to HIV-1. Our study underscores the need for integrated diagnostic and therapeutic strategies to improve patient care in resource-limited settings. Understanding these interactions is crucial for developing effective management approaches for patients with HIV, HBV, and HCV coinfections.
Keywords
HIV-1; coinfection; hepatitis; Warri; Humoral immune response


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