Therapeutic Strategies for Asthma Concurrently Occurred with Obesity. | ||||
| Records of Pharmaceutical and Biomedical Sciences | ||||
| Volume 8, Issue 3, 2024, Page 23-30 PDF (782.59 K) | ||||
| Document Type: Mini-reviews | ||||
| DOI: 10.21608/rpbs.2024.283448.1290 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Rania Talaat Kamal Ibrahim  1; Dina M. Khodeer 2; Yasserr M. Mustafa3
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| 1Pharmacology &Toxicology Dep., Pharmacy, Suez canal university. Ismailia | ||||
| 2Department of Pharmacology & Toxicology, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt | ||||
| 3department of pharmacology& toxicology, faculty of Pharmacy. Suez canal university | ||||
| Abstract | ||||
| One of major global problems is obesity, which can lead to inflammation in the form of hyperlipidemia, lung abnormalities, and asthma. An abnormal buildup of fat that poses a risk to health is obesity. The incidences of obesity in adults and children are still rising. Obesity is a disease that has a significant impact on asthma in both adults and children. Excessive obesity-induced systemic inflammation has been linked to the physiopathology of a number of diseases and has been suggested as a potential mechanism for the onset of asthma in obese people. Obesity-related inflammation is thought to be caused by M1 macrophage infiltration of adipose tissue and elevated expression of several mediators that intensify and spread inflammation. Adipose tissue serves as a significant reservoir for adipokines, including the pro-inflammatory leptin that is overpro8duced in obesity and the anti-inflammatory adiponectin that is synthesized at a reduced rate. Pro-inflammatory cytokines like IL-1β, TNFα, and NF-KB are synthesized during the inflammatory process and play a role in the pathogenesis of asthma. The objective of this review is to evaluate the role of medication in treatment obesity and its influence in improve asthma. | ||||
| Keywords | ||||
| Obesity; asthma; inflammatory markers; medication | ||||
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