Protective immunity induced by co-injection of mixture of Mannan and B- glucan immunostimulant substances with the inactivated Bivalent AI-ND vaccine in broiler chickens
A, H., A, S., A, S., M, S., A, N., A, E. (2011). Protective immunity induced by co-injection of mixture of Mannan and B- glucan immunostimulant substances with the inactivated Bivalent AI-ND vaccine in broiler chickens. EKB Journal Management System, 57(4), 649-667. doi: 10.21608/vmjg.2011.368055
Hussein A; Shereen A; Sultan A; Samah M; Nada A; El Sanousi A. "Protective immunity induced by co-injection of mixture of Mannan and B- glucan immunostimulant substances with the inactivated Bivalent AI-ND vaccine in broiler chickens". EKB Journal Management System, 57, 4, 2011, 649-667. doi: 10.21608/vmjg.2011.368055
A, H., A, S., A, S., M, S., A, N., A, E. (2011). 'Protective immunity induced by co-injection of mixture of Mannan and B- glucan immunostimulant substances with the inactivated Bivalent AI-ND vaccine in broiler chickens', EKB Journal Management System, 57(4), pp. 649-667. doi: 10.21608/vmjg.2011.368055
A, H., A, S., A, S., M, S., A, N., A, E. Protective immunity induced by co-injection of mixture of Mannan and B- glucan immunostimulant substances with the inactivated Bivalent AI-ND vaccine in broiler chickens. EKB Journal Management System, 2011; 57(4): 649-667. doi: 10.21608/vmjg.2011.368055

Protective immunity induced by co-injection of mixture of Mannan and B- glucan immunostimulant substances with the inactivated Bivalent AI-ND vaccine in broiler chickens

Veterinary Medical Journal (Giza)
Volume 57, Issue 4, October 2009, Page 649-667  XML PDF (5.73 MB)
Document Type: Original Article
DOI: 10.21608/vmjg.2011.368055
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Authors
Hussein A1; Shereen A2; Sultan A3; Samah M2; Nada A2; El Sanousi A1
1Department of Virology, Faculty of Veterinary Medicine, Cairo University, Giza-Egypt.
2Department of Immunology, Animal Health Research Institute-Dokki Giza.
3Department of Poultry Diseases, Faculty of Veterinary Medicine, Menoufia University-Sadate City-Egypt
Abstract
In the present study, the effect of a mixture of some immunostimulant substances on the immune response of broiler chicks to bivalent AI-ND vaccine was determined. Four groups of chicks were used. Group 1 was vaccinated with one dose of AI-ND vaccine and simultaneously injected with the mixture of immunostimulant substances. Group 2 was vaccinated with one dose of the bivalent AI-ND vaccine. Group 3 was vaccinated with 2 doses of live ND vaccines (Hitchner then Lasota Strains) and group 4 was kept none vaccinated as control chicks. All birds were monitored Weekly for the humoral and cellular immune response then challenged with the virulent NDV at 35 days of age. HI test was used for titration of antibodies for both AIV and NDV, phagocytic activity, Nitric oxide; Lysozyme activity and total antioxidant in serum were used to determine the cellular immune response of the chicks. Protective immunity induced in the vaccinated groups varied. The injected immunostimulant mixture demonstrates its effect on the immune response to the bivalent AI-ND vaccine in group 1 with 100% protection against the challenge NDV. Whereas, 80 and 60 % protection were obtained in chicks vaccinated either with AI-ND vaccine (group 2) or live ND vaccines (group 3); respectively. The present study reports the effect of injection of some immunostimulant substances in augmentation of the immune response to the inactivated vaccinens.
 
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