Biochemical and Immunological Parameters in HIV Seropositive Subjects on TLD Southsouth Nigeria

Odegbemi, Odekunle Bola; Olaniyan, Mathew Folaranmi; Ugege, Christian Onosetale; Adebo, David Olufemi; Muhibi, Musa Abidemi

doi:10.21608/mid.2024.300145.2033

	Biochemical and Immunological Parameters in HIV Seropositive Subjects on TLD Southsouth Nigeria
Microbes and Infectious Diseases
Articles in Press, Accepted Manuscript, Available Online from 20 July 2024
Document Type: Original Article
DOI: 10.21608/mid.2024.300145.2033
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Authors
Odekunle Bola Odegbemi ¹^{, 2}; Mathew Folaranmi Olaniyan ¹; Christian Onosetale Ugege ¹; David Olufemi Adebo ¹; Musa Abidemi Muhibi ¹
¹Medical Laboratory Department, Edo State University, Uzairue, Edo State, Nigeria
²Medical Laboratory Department, Nigerian Navy Hospital Warri, Edo State, Nigeria
Abstract
Background: HIV infection remains a significant global health challenge, particularly in Sub-Saharan Africa. While antiretroviral therapy (ART) has improved outcomes for people living with HIV (PLHIV), limited data exists on the biochemical and immunological effects of the preferred first-line regimen, Tenofovir, Lamivudine, and Dolutegravir (TLD), in specific regional contexts like South-South Nigeria. This study aimed to investigate the differences in biochemical and immunological parameters between HIV seropositive subjects on TLD and healthy controls in this region. Methods: We conducted a cross-sectional study at the Nigerian Navy Hospital in Warri, Nigeria. We recruited 100 HIV-positive participants receiving TLD, and 100 HIV-negative controls were included. Blood samples were analyzed for sodium (Na⁺), potassium (K⁺), chloride (Cl¯), urea, creatinine (Crt), C-reactive protein (CRP), glutathione S-transferases (GSTs), uromodulin (UMOD), nephrin (Neph), and interleukin-10 (Il 10). We used Student's t-test and Pearson correlation coefficients for statistical analysis. Results: HIV seropositive subjects on TLD exhibited significantly higher sodium levels, elevated urea and creatinine, increased CRP and GSTs, lower UMOD, higher Neph, and reduced IL-10 levels compared to HIV-negative controls. Conclusion: HIV seropositive subjects on TLD in South-South Nigeria exhibit significant alteratioguy ns in renal function, inflammatory responses, oxidative stress, and anti-inflammatory cytokine levels compared to HIV-negative controls. These findings underscore the importance of comprehensive biochemical and immunological monitoring in this population to optimize patient care and inform treatment strategies.
Keywords
HIV infection; Antiretroviral therapy (ART); Biochemical parameters; Immunological effects; Tenofovir Lamivudine Dolutegravir (TLD)


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