Improvement of Polyvalent Clostridial Vaccine | ||
| Veterinary Medical Journal (Giza) | ||
| Volume 59, Issue 3, July 2011, Pages 39-46 PDF (1.18 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/vmjg.2011.368229 | ||
| Authors | ||
| Abdalla A* 1; El-Meneisy A1; El-Schiemy M1; Hussien S1; Ebtesam El-Sayed2; Fathia Shafie1 | ||
| 1Veterinary Serum and Vaccine Research Institute, Abbassia, Cairo, Egypt | ||
| 2Animal Fertility and Reproduction Research Institute, Harram, Giza, Egypt | ||
| Abstract | ||
| Rabbits, sheep and cattle were vaccinated with a prepared polyvalent clostridial vaccine adjuvenated with either alum or gel after addition of alpha toxoid of C. perferingens type A to polyvalent vaccine. The immune response of rabbits and sheep to the different components of the two vaccines was higher than these in cattle. The antitoxic values of rabbits, sheep and cattle for alpha and beta toxoid of C. perfringens type A and B, alpha toxoid of C. septicum and alpha toxoid of C. novyi type B in rabbits, sheep and cattle were higher in gel vaccine than in alum one, but the response to epsilon toxoid of C. perferingens type D was the same in both vaccines. Also the immune response of tetanus toxoid of C. tetani antigens and antigens of C. chauvoel bactrein and toxoid were higher in alum vaccine than in gel one. Finally both vaccines (alum and gel adjuvenated) gave satisfactory antibody titres which were higher than the minimum protective levels for all antigen components of both improved polyvalent clostridial vaccine. | ||
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