The use of Swiss mice in comparison with the specific host for the evaluation of live attenuated Salmonella Typhimurium and Salmonella Enteritidis vaccine for chicken | ||
| Veterinary Medical Journal (Giza) | ||
| Volume 59, Issue 3, July 2011, Pages 73-81 PDF (1.39 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/vmjg.2011.368232 | ||
| Authors | ||
| Salama S* ; Afaf Khedr; Makharita A; Elham Elebiary | ||
| Central Laboratory for Evaluation of Veterinary Biologics (CLEVB). | ||
| Abstract | ||
| In this study, a total of 600 SPF chicks and 1200 Swiss mice were used to compare between both in the evaluation of live Salmonella Enteritidis and Salmonella Typhimurium vaccines. Results revealed that, 81% and 78% protection were obtained after vaccination and challenge with Salmonella Enteritidis and Salmonella Typhimurium respectively. At the same time, the Swiss mice gave protection reached to 74% and 71% for both organisms when vaccinated and challenged orally, while gave 80% and 82% when vaccinated and challenged intraperitoneally, respectively. The results showed that, the Swiss mice could be used as model in the evaluation of live salmonella vaccines specially when the intraperitoneal route was used in the vaccination and evaluation programs. | ||
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