Comparative Neuroprotective Activities of the Ethanol Extracts of Washingtonia filifera | ||||
| Journal of Advanced Medical and Pharmaceutical Research | ||||
| Volume 5, Issue 2, September 2024, Page 105-112 PDF (594.98 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jampr.2024.285984.1068 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Aalaa Salem; El-Sayed Marwan; Saleh H. El-Sharkawy; Amira Mira  
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| Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University. | ||||
| Abstract | ||||
| The present study aimed to the in vitro investigation of the ethanol extracts of Washingtonia filifera roots (W.R), barks (W.B), leaves (W.L), fruitless bunches (W.F) and seeds (W.S) for their neuroprotective activities including the phenolic content, antioxidant activity, anti-inflammatory activity and the potentiality to protect mouse neuroblastoma (neuro-2A) cells against H2O2 and Aβ1-42 -induced neurotoxicity. Among the extracts, W.L and W.F had the highest phenolic content; 226.7 and 172.3 GAE, respectively. Consequently, W.L and W.F showed pronounced DPPH radical scavenging activity with IC50 values of 19.95 and 30.46 µg/mL, respectively. The highest inhibitory potential of COX-2 was achieved by W.F then W.L with IC50 values of 111.62 and 191.77 µg/mL. The most efficient extract for the neuroprotection against H2O2 and Aβ1-42 -induced neurotoxicity was W.F which had more potent activity than the positive control in Aβ1-42 assay. To the best of our knowledge, this is the first report to indicate the neuroprotective activities of W. filifera leaf and the fruitless bunch extracts. | ||||
| Keywords | ||||
| H2O2; Aβ1-42; anti-inflammatory, neuroblastoma | ||||
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