Porous microparticles as a tool for minimizing 5-Fluorouracil induced intestinal mucositis. | ||
| Merit Medical Journal | ||
| Volume 1, Issue 1, January 2024, Pages 21-27 PDF (896.45 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mermj.2024.272097.1012 | ||
| Authors | ||
| Ahmed U. Ali* 1; Heba AbbouTaleb2; Ahmed Haredy3; Mohammed Thabit4; heba Mubarak5; Mahmoud Elbadry6; Tahani Elfaham6 | ||
| 132- El sahel street, Assuit-Egypt | ||
| 24. Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Merit University, Sohag 82755, Egypt; heba.ahmed@merit.edu.eg | ||
| 3Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Merit University, New Sohag, Egypt | ||
| 4Lecturer of pharmaceutical organic chemistry and medicinal chemistry – Faculty of pharmacy – Merit University, Sohag, Egypt. | ||
| 5Department of Histology, Faculty of Medicine, Assiut University, Assiut, Egypt. | ||
| 6Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, 71526, Egypt. | ||
| Abstract | ||
| 5 Fluorouracil (5-FU) is used primarily to treat solid malignant tumors and is administered via the intravenous route; however, this administration is accompanied by intestinal mucositis, represented by diarrhea. In this work, 5-FU microsponges (porous microparticles) were prepared to be taken orally to minimize the intestinal mucositis associated with the intravenous IV administration of 5-FU. 15 male albino rabbits were utilized to compare the degree of intestinal mucositis related to the intravenous administration to that of 5-FU microsponges capsule oral administration (at the same dose). The experiment was conducted for five consecutive days. Results showed that the mean villus height of the IV group measured about 260.0± 6.9 µm, which was considerably lower (p<0.05) than that of the Capsule group, which measured about 285.0± 9.3 µm; in addition, the mean depth of crypts of IV group measured about 110.0± 6.8 µm which is significant (p<0.05) lower than that of Capsule group which measured about 141.0± 7.8 µm which means that the degree of intestinal mucositis induced by the intravenous injection of 5-FU was significantly higher than that caused by that of oral administration of 5- FU microsponges formulation. By the way, on the fourth day, one rabbit of the IV group died, indicating the severity of the intestinal mucositis after the IV administration of 5-FU. The results showed that the oral administration of 5-FU microsponges is more safe than IV drug administration at the same dose. | ||
| Keywords | ||
| 5-Fluorouracil; oral administration; mucositis; and histological study | ||
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