Effect of Capparis spinosa leaves on some haematological and histopathological changes associated with exposure of mice to trichloroacetic acid.
Alzergy, A., Elgharbawy, S., Mahmoud, G. (2014). Effect of Capparis spinosa leaves on some haematological and histopathological changes associated with exposure of mice to trichloroacetic acid.. EKB Journal Management System, 60(3), 1-28. doi: 10.21608/vmjg.2014.368837
Aglal Alzergy; Saad Elgharbawy; Ghyath Mahmoud. "Effect of Capparis spinosa leaves on some haematological and histopathological changes associated with exposure of mice to trichloroacetic acid.". EKB Journal Management System, 60, 3, 2014, 1-28. doi: 10.21608/vmjg.2014.368837
Alzergy, A., Elgharbawy, S., Mahmoud, G. (2014). 'Effect of Capparis spinosa leaves on some haematological and histopathological changes associated with exposure of mice to trichloroacetic acid.', EKB Journal Management System, 60(3), pp. 1-28. doi: 10.21608/vmjg.2014.368837
Alzergy, A., Elgharbawy, S., Mahmoud, G. Effect of Capparis spinosa leaves on some haematological and histopathological changes associated with exposure of mice to trichloroacetic acid.. EKB Journal Management System, 2014; 60(3): 1-28. doi: 10.21608/vmjg.2014.368837

Effect of Capparis spinosa leaves on some haematological and histopathological changes associated with exposure of mice to trichloroacetic acid.

Veterinary Medical Journal (Giza)
Volume 60, Issue 3, July 2014, Page 1-28  XML PDF (13.63 MB)
Document Type: Original Article
DOI: 10.21608/vmjg.2014.368837
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Authors
Aglal Alzergy email 1; Saad Elgharbawy2; Ghyath Mahmoud3
1Department of Anatomy and Embryology, faculty of Veterinary medicine, Omar El- Mukhtar University, Albayda- Libya.
2Department of Anatomy and Embryology, faculty of Veterinary medicine, Omar El- Mukhtar University, Albayda- Libya. Department of Cytology and Histology, Faculty of Veterinary Medicine Cairo University
3Department of Animal Science Faculty of Science Benghazi University.
Abstract
The present work was conducted to study the possible protective role of Capparis spinosa leaves and their efficacy against hematological and histological alterations resulted in an animal model intoxicated with trichloroacetic acid (TCA). Hundred male mice 20-26 gm were divided into 5 groups; control group, group II treated orally with honey (40 mg/kg body weight for 3 weeks), group Ⅲ treated orally with a mixture of Capparis spinosa leaves powder and honey(40 mg/kg for 3 weeks), group IV treated with TCA in drinking water (500mg/kg for 3 and 6 weeks, then left for 3 weeks for recovery) and group V (Regeneration group) treated with TCA for 6 weeks then treated with a mixture of Capparis and honey (40 mg/kg for 3 weeks). Marked disturbance in the hematological parameters was demonstrated in mice treated with TCA for 3 and 6 weeks. Mice treated with TCA then with a mixture of Capparis spinosa leaves powder and honey showed an improvement in total leukocytic count and percentage of lymphocytes comparing to TCA treated group. Also, significant improvement in the platelets count was demonstrated. Histological examination of spleen sections of mice treated with TCA revealed obvious pathological findings including disorganization of lymphoid follicles, hyperplasia in white pulp, depletion of lymphocytes in red pulp with sub capsular edema, some necrotic cells in white and red pulp, increasing megakaryocytes, haemosiderosis and fibrosis in red pulp and in some lymphoid follicles. Administration of a mixture of Capparis spinosa leaves powder and honey lessened most of the pathological lesions in mice intoxicated with TCA.
Keywords
Capparis spinosa; trichloroacetic acid; hematological; histopathological changes; spleen; mice (Mus musculus)
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