COMPARATIVE PATHOLOGICAL AND IMMUNOLOGICAL STUDIES ON DIFFERENT OIL ADJUVANATED INACTIVATED NEWCASTLE DISEASE VIRUS VACCINES (NDVV) PRIVATE
ABD EL-HADY, A., EL-EBIARY, E., OSMAN, A., HASSAN, N. (2002). COMPARATIVE PATHOLOGICAL AND IMMUNOLOGICAL STUDIES ON DIFFERENT OIL ADJUVANATED INACTIVATED NEWCASTLE DISEASE VIRUS VACCINES (NDVV) PRIVATE. EKB Journal Management System, 50(4), 769-778. doi: 10.21608/vmjg.2002.369353
AMAL ABD EL-HADY; ELHAM EL-EBIARY; a OSMAN; NADIA HASSAN. "COMPARATIVE PATHOLOGICAL AND IMMUNOLOGICAL STUDIES ON DIFFERENT OIL ADJUVANATED INACTIVATED NEWCASTLE DISEASE VIRUS VACCINES (NDVV) PRIVATE". EKB Journal Management System, 50, 4, 2002, 769-778. doi: 10.21608/vmjg.2002.369353
ABD EL-HADY, A., EL-EBIARY, E., OSMAN, A., HASSAN, N. (2002). 'COMPARATIVE PATHOLOGICAL AND IMMUNOLOGICAL STUDIES ON DIFFERENT OIL ADJUVANATED INACTIVATED NEWCASTLE DISEASE VIRUS VACCINES (NDVV) PRIVATE', EKB Journal Management System, 50(4), pp. 769-778. doi: 10.21608/vmjg.2002.369353
ABD EL-HADY, A., EL-EBIARY, E., OSMAN, A., HASSAN, N. COMPARATIVE PATHOLOGICAL AND IMMUNOLOGICAL STUDIES ON DIFFERENT OIL ADJUVANATED INACTIVATED NEWCASTLE DISEASE VIRUS VACCINES (NDVV) PRIVATE. EKB Journal Management System, 2002; 50(4): 769-778. doi: 10.21608/vmjg.2002.369353

COMPARATIVE PATHOLOGICAL AND IMMUNOLOGICAL STUDIES ON DIFFERENT OIL ADJUVANATED INACTIVATED NEWCASTLE DISEASE VIRUS VACCINES (NDVV) PRIVATE

Veterinary Medical Journal (Giza)
Volume 50, Issue 4, October 2002, Page 769-778  XML PDF (2.86 MB)
Document Type: Original Article
DOI: 10.21608/vmjg.2002.369353
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Authors
AMAL ABD EL-HADY* 1; ELHAM EL-EBIARY1; a OSMAN2; NADIA HASSAN3
1Central Laboratory for Control of Veterinary Biologics, Abbasia, Cairo.
2Department of Pathology, Faculty of Veterinary Medicine, Cairo University
3Veterinary Serum and Vaccine Research Institute, Abbasia, Cairo.
Abstract
The present study was applied to evaluate the physical properties of ISA-70 Marcol-52 and paraffin oil adjuvant used in commercial vaccines and describes the pathological changes and serological response of chickens after intramuscular injection. A total of 140 three-week old white Leghorn chickens, specific pathogen free were obtained from Koum Osheim, Fayoum Governorate. Chickens were divided into four equal groups one of them is control, the other three groups were in- jected intramuscularly with the following oil adjuvant emulsions containing inactivated Newcastle disease virus (NDV) antigen: ISA-70, Marcol-52 And paraffin. Five chickens of each group were Sacrificed at 72 hours and at 1, 2, 4, 8, 12 and 16 weeks post-vaccination.
The pathological reaction induced by ISA-70 emulsion was characterized by focal aggregation of macrophages, lymphocytes, epithelioid cells and fibroblasts around the small cysts in muscle. These lesions peaked at 2 weeks post-injection and considered as mild pathological changes if compared with Marcol-52 and paraffin oil adjuVant. The serological findings revealed that the enhancing effect of ISA-70 on NDV antigen was more than that of Marcol-52 and paraffin oil adjuVant.
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