Ameliorative Effect of Parsley and Pumpkin Seeds Oils against Cosplatin Induced Hepatorenal Injury in Male Albino Rats (Physiological and Histological Study) | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 51, Volume 96, Issue 1, July 2024, Page 2672-2679 PDF (1.1 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejhm.2024.369500 | ||||
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| Abstract | ||||
| Background: Cisplatin is a widely used chemotherapeutic agent with significant hepatotoxic and nephrotoxic side effects. Objective: This study aimed to investigate the protective effects of parsley oil (PO) and pumpkin seed oil (PSO) against cisplatin-induced organ toxicity in male albino rats. Methods: A batch of male albino rats weighing between 160 and 200 grams was divided into four groups. Group 1 functioned as the control group. Group 2 was administered a solitary dose of cisplatin at a dosage of 7.5 mg per kilogram of body weight, intraperitoneally. Groups 3 and 4 were pre-treated with PO or PSO (0.1 ml/kg BW, orally) for ten days and then received cisplatin on the sixth day. On day 11, blood samples were obtained for biochemical examination. Histopathological examination of kidney samples was also conducted. Results: Cisplatin administration significantly elevated ALT, AST, urea, and creatinine levels, indicating liver and kidney damage. Pre-treatment with PO and PSO significantly mitigated these effects, normalizing the biochemical markers. Histopathological analysis supported these findings, showing reduced tissue damage in PO and PSO groups. Conclusion: Parsley oil and pumpkin seed oil provided defense against liver and kidney damage caused by cisplatin in rats, suggesting their potential as adjuncts in chemotherapy. | ||||
| Keywords | ||||
| Cisplatin; Hepatotoxicity; Nephrotoxicity; Parsley oil; Pumpkin seed oil; Antioxidants; Chemotherapy | ||||
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